Re: How long before export can continue?

AJH wrote:
2007 there has been no evidence to show a vaccinated animal will
excrete live virus.

They will if challenged
http://www.fao.org/AG/AGAINFO/commissions/en/documents/reports/paphos/App53Parida.pdf
Introduction: The 2001 outbreak in the UK showed that strict movement
controls combined with
the stamping out of infected and contact animals are not always sufficient
to eradicate FMD quickly,
have high economic costs and cause great public alarm. In future, a policy
of vaccinate-to-live may
be included in the repertoire of control measures and in support of this
approach, we have
investigated: a) The efficacy of emergency FMD vaccine in pigs, b) The
reduction in virus excretion
from vaccinated and then infected pigs, c) The ability to detect infection
in vaccinated pigs and d)
The persistence of FMDV in the oropharynx of pigs.
Materials and Methods: Two groups (n=16 and n=8) of O1 Manisa vaccinated
pigs were exposed to
direct contact challenge with O1 UKG 2001 FMDV infected pigs for nine hours
at 10 and 29 days
after vaccination respectively. Thereafter, the pigs were monitored for a
minimum another 30 days.
Excretion of virus in nasal and oro-pharyngeal secretions and in exhaled air
was measured by virus
isolation and real time RT-PCR. Three different commercial serology ELISAs
that detect antibodies
to FMDV non-structural proteins (NSP) were evaluated for detection of
infection in vaccinated
animals. Cell mediated immune responses were also measured to study their
relationship to
protection and infection.
Results: Three out of 16 and six out of eight pigs were clinically
protected. Although vaccination
could not provide complete clinical or virological protection, it reduced
virus excretion in infected
pigs. Infection in vaccinated pigs was detected by NSP tests, even where
infection was sub-clinical.
IgA ELISA is considered as a potential candidate to detect infection in
vaccinated infected pigs.


--

regards
Jill Bowis

Pure bred utility chickens and ducks
Housing; Equipment, Books, Videos, Gifts
Herbaceous; Herb and Alpine nursery
Working Holidays in Scotland
http://www.kintaline.co.uk


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