H5N1 continues to evolve


http://www.recombinomics.com/News/07150601/H5N1_Niger_Recombination.html

H5N1 Evolution Via Recombination in Niger

Recombinomics Commentary
July 15, 2006

The sequences of two more isolates from Niger,
A/chicken/Niger/2130-7/2006(H5N1) and A/chicken/Niger/2130-8/2006(H5N1) were
published today at GenBank. These sequences were closely related to the
earlier sequence from Niger, A/duck?niger/914/2006. The two new isolaets do
not have G1252A, which is found in the bar headed goose isolate from
Mongolia. However, 2130-7 has T1090G, which is found in all three chicken
isolates from the Crimea. 2130-8 has A1019G, which is found in several H5
isolates from Europe.

These acquisitions, placed on a Qinghai genetic background, create
additional discordance, creating additional examples of acquisition via
recombination. Further evidence of novel acquisitions was provided bt
another sequence released today, A/mallard/Italy/3401/2005(H5N1). Although
the isolate is low path, it contains, A295G, which is also found in Qinghai
bird flu isolates from Bavaria and Turkey.

The Qinghai strain is expanding its geographical reach and acquiring new
polymorphisms. Moreover, the Qinghai isolates are recombining with each
other and evolving rapidly

These two new isolates from Niger provide additional evidence for newe
sequences and new problems in the fall in the northern hemisphere


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regards
Jill Bowis

Pure bred utility chickens and ducks
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