Re: Avian Flu, BSE and FMD


"Pat Gardiner" <patgardiner@xxxxxxxxxxxxxx> wrote in message >
> The virus has already mutated. That stable door can't be closed.

http://www.promedmail.org/pls/promed/f?p=2400:1001:16306418344298210439::NO:
:F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,30213
An outbreak of highly pathogenic avian influenza A (H5N1) has recently
spread to poultry in 9 Asian countries. H5N1 infections have caused 52
human deaths in Viet Nam, Thailand, and Cambodia from January 2004 to April
2005. Genomic analyses of H5N1 isolates from birds and humans showed 2
distinct clades with a non-overlapping geographic distribution. All the
viral genes were of avian influenza origin, which indicates absence of
reassortment with human influenza viruses. All human H5N1 isolates tested
belonged to a single clade and were resistant to the adamantane drugs but
sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were
antigenically homogeneous and distinct from avian viruses circulating
before the end of 2003. Some 2005 isolates showed evidence of antigenic
drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic
cleavage site in the hemagglutinin gene, was produced by reverse genetics
in anticipation of the possible need to vaccinate humans.

.

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