Re: Delayed Treatments for Prostate Cancer


"george conklin" <george@xxxxxxx> wrote in message
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"Skeptic" <bcs002b@xxxxxxxxx> wrote in message
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New data in this month:

13 year outcomes study results are in. Isn't this the kind of stuff YOU
are looking for, George? It showed that for low, intermediate, and high
risk prostate cancers, there was a significant survival advantage for
radical prostatectomy over active surveillance, even after adjusting for
age, pathology, etc. on multivariate analysis. These are results from
Dr. Albertsen of UConn and based on the results of the Connecticut Tumor
Registry. A nice feature of this study is that every patient's slides
(almost 2,000) were reviewed by a single pathologist. This is important
nowadays since there has been a "stage migration" of prostate cancer over
the last decade or so.

They had great followup with 75% of patients having more than 12.8 years
of followup. At this timepoint, they found that "mortality rates were
2.5 and 3.2 times higher for radiation therapy and observation,
respectively, compared with surgery across all of the categories".

These results are in the August issue of the AUA News, a monthly
publication.

This is more supportive evidence that surgery not only greatly improves
survival (3 fold increased risk of death without surgery is a huge
change) but also is equally efficacious for those with low grade low
volume disease as it is with men with high grade high volume disease
(excluding those with metastatic disease of course).

There is some "real world" outcomes data for ya buddy.

So what about a URL? And given the self-selection process just
illustrated from the Journal of the National Cancer Institute, how as that
bias controlled for?

I don't know of a link. I have a hard copy and don't know if it's even
accessible via the web. There was no bias in selection - they looked at all
prostate cancer patients, determined if they got radiation, surgery, or
neither, and reviewed their outcomes. 3 fold decrease in overall mortality
with surgery.

You wanted outcomes. There's some outcome data from the state of
Connecticut.


.

Relevant Pages

  • Re: Delayed Treatments for Prostate Cancer
    ... 13 year outcomes study results are in. ... This is more supportive evidence that surgery not only greatly improves ... There is some "real world" outcomes data for ya buddy. ... all prostate cancer patients, determined if they got radiation, surgery, ...
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