Re: Delayed Treatments for Prostate Cancer


"george conklin" <george@xxxxxxx> wrote in message
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"Skeptic" <bcs002b@xxxxxxxxx> wrote in message
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"george conklin" <george@xxxxxxx> wrote in message
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The issue is to what degree surgery, by any technique, is going to do
much for a patient. You point to a 3% difference over 10 years as a
major victory, even while the big studies, much delayed, are just
getting started. One has been going 10 years with no results announced
yet.

NEJM V347(11) from Sept 2002:
studied 700 men with prostate cancer. Median f/u of 6 years (not
adequate for prostate cancer studies) showed an improved disease specific
survival - a decrease from 8.9% to 4.6% which is a 48% reduction.


So, go tell government to get rid of the PIVOT studies since
everything has been decided. 700 men? And from that pitifully small
number you are going to treat millions? Horrid.

We have the studies that we have. It's not easy to RANDOMIZE men to
treatment vs. no treatment. Only time will tell what PIVOT shows.

NEJM V352(19) from May 2005
Same group with longer followup, now out to 8 years (still not adequate).
Showed that "radical prostatectomy reduces disease specific mortality,
overall mortality, and the risks of metastasis and local progresssion".
Overall survival was improved by 22%. Not 3%...... but 22%. That was
statistically and is clinically significant.


3% of a sample turns into 22% 'reduction.' A committee had to decide
what the men really died of, since there were multiple causes. Just a few
differences in committee opinion would have changed the result since you
are dealing with a small sample. You know that too, but you cannot fool
the whole world with nasty posts. I still view you as once reason why
research into female cancers is so advanced compared to men. Neither is
all that good, but women have been politically active against attitudes
like yours.

22% improvement in survival. Bitch all you want - that's what the data
shows - a 22% improvement in survival after just 8 years of followup.


.

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