Re: They really piss me off. (Honestly, they really do).

On May 16, 2:14 am, spintronic <spintro...@xxxxxxxxxxx> wrote:
On 16 May, 00:43, John Harshman <jharshman.diespam...@xxxxxxxxxxx>
wrote:



Ernest Major wrote:

You [spintronic] could at least try to appear as if you were trying to make
an argument.

No, I think he's really trying. He's just so bad at it that it's hard to
figure out what he's trying to say. Nor is he capable of following your
argument.

So are we agreed that the effective population of the ark would allow at
most 10 alleles for each autosome, 2 each for Noah, his wife, and the 3
sons' wives? We also have a maximum of 1 Y-linked allele, 8 X-linked
alleles, and 3 mitochondrial haplotypes.

This is all because Noah's sons contributed no new alleles of their own,
  and Noah and his wife had no other children than those three sons.

Now of course it may be spinny's point that mutation can introduce new
alleles. But if he's claiming it works as fast as necessary to produce
all human allelic diversity in 5000 years, that's sure hyperevolution.

You're wrong actually.

0.4% would have copy number variation, so 3.2 people on the ark would
have different CNV.

What does "have copy number variation" mean? The grammar of the
sentence makes it a property of one person, but even allowing that the
intention is something related to a group of people the meaning is
unclear.

Is "different CNV" a typo for "different CN"?

Is 3.2 people calculated by taking 0.4% of something?

which in simple terms would means that that particular section of DNA
would
undergo twice the mutation rate per CNV per whatever the mutation rate
is.

Since extra copies can be removed or added whenever two people with
diff CNV mate,
you would think the diversity spans a longer time than it actually
does.

Are you imagining that recombination and mutation are two different
things, so that recombination enhances diversity on top of the 0.4%
from mutation? That would be wrong. Recombination is a type of
mutation. Most of the 0.4% mutation rate of VNTRs *is* recombination
-- shuffling that causes a change in repeat number, not base
substitution (which is rare).

(However, VNTR mutation can be as high as 15% -- Buard J, Brenner CH,
Jeffreys AJ, Evolutionary fate of an unstable human minisatellite
deduced from sperm mutation spectra of individual alleles, Am J Hum
Genet 70:1038-1043. Does that help you?)

Why bring VNTRs in anyway? Are they inherited from a previous thread?

.

Relevant Pages

  • Re: Added information with mutations
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  • Re: rates of change of mitochondrial DNA
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  • Re: rates of change of mitochondrial DNA
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  • Re: Haldanes Dilemma - clarifications - and Felsenstein [LONG]
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    (sci.bio.evolution)
  • Re: Question: How to recognize mutations
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