Re: Moving the Islands within Sequence Space

On Jan 25, 2:08 pm, Seanpit <sean...@xxxxxxxxx> wrote:
On Jan 8, 11:54 pm, "R. Baldwin" <res0k...@xxxxxxxxxxxxxxxxxxxx>
wrote:





Seanpit <sean...@xxxxxxxxx> wrote innews:6cee2bbe-63a6-4a27-ada0-605ea814f291@xxxxxxxxxxxxxxxxxxxxxxxxxxxx:

On Jan 8, 7:33 pm, "R. Baldwin" <res0k...@xxxxxxxxxxxxxxxxxxxx> wrote:
Seanpit <sean...@xxxxxxxxx> wrote in news:2fdb2619-c052-4fda-ac3b-
97f1505d9...@xxxxxxxxxxxxxxxxxxxxxxxxxxxx:

On Jan 7, 9:00 pm, "R. Baldwin" <res0k...@xxxxxxxxxxxxxxxxxxxx>
wrote
:

You have no clue what you're talking about.  The Poisson
distribution isn't a "process".

Please look up "Poisson process" on wikipedia and stop
pretending that you know what you are talking about.

I'm not using a "Poisson process" in my arguments.  I'm using a
Poisson distribution.  Look that up.

Sean, I suggest you follow Mr. Stockwell's suggestion and read
about
Poisson processes. Mr. Stockwell did not tell you that a Poisson
distribution is a Poisson process. If you read about Poisson
processes,
then you would understand what he meant, and learn something to
boot.

From Wikipedia:  "A Poisson process, named after the French
mathematician Siméon-Denis Poisson (1781 – 1840), is the stochastic
process in which events occur continuously and independently of one
another (the word event used here is not an instance of the concept
of event frequently used in probability theory)."

What I'm describing is only a Poisson process in the sense that
random mutations do in fact occur continuously and independently of
one another in different individual organisms and even different
individual sequences.  

Well, at least this is progress from "I'm not using a "Poisson
process" in my arguments. I'm using a Poisson distribution." Do you
understand yet why Mr. Stockwell corrected you, and that he was
absolutely correct in discussing the Poisson process in your model?

It wasn't apparent to me that he was actually discussing the Poisson
process of random mutations.  That's obvious.  What is completely
missed is the fact that the odds of hitting upon a target are in fact
dependent upon the ratio of targets vs. non-targets.

Yes, we know, if you are searching a sparsely populated large space with
a random search.

Other than that, my description of the odds of
finding rare targets with unknown locations in sequence space by a
process of random mutations seems to be completely missed by both
you and Stockwell.

No, we haven't missed your description. We've tried to explain why it
does not agree with reality (so have others), but it appears you
haven't been willing to listen.

You have tried, unsuccessfully, to challenge my math.  

I have more than once successfully corrected your math, and you've
acknowledged it at least twice, as you might recall. I made a mistake in
this thread and self-corrected it on the same day..

Tell me, what
else do you have?  You won't present your own alternative model
because, as you say, you aren't a biologist.  You really have no idea
how RM/NS is capable of doing the job.  

Actually, I do have an idea, by reading articles by biologists.

Yet, somehow, you just know
that my model is flawed.  How, pray tell?  Please, do present
something relevant this time.

Because your model arm-waves away fundamental research about how
proteins actually evolve in only two sentences, yet provides no
supporting evidence.

Your papers only talk about protein evolution below 100aa.  My model
is talking about evolution where the minimum requirement is greater
than 1000aa.  Have anything relevant to that problem?



There IS nothing relevantr to that problem, Sean, because there is no
"problem".

YOU can insist if you want that large proteins and multi-protein
assemblies have to appear all at once, intact, in one fell swoop, like
a 747 appearing in a tornado.

The rest of us, alas, are under no obligation to take your silly
insistence seriously.


Tell me again why smaller subunits cannot be pieced together into
larger assemblies? Why, again, can't 3 different sequences of 333
units be joined into a single sequence of 1000?

How did mammalian inner ear bones result from the coopting of
reptilian jawbones?

How did the bacterial flagellum come to contain pieces of the cellular
excretarory apparatus?

(sound of crickets chirping)

Yeah, that's what I thought.

You are a liar, Sean. A deliberaste calculating intentional liar.




================================================
Lenny Flank
"There are no loose threads in the web of life"


Editor, Red and Black Publishers
http://www.RedandBlackPublishers.com


.

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