Re: How Our Brains Ignore Unpleasant Facts was: Re: The Reasonable

Evopeach wrote:
On Jan 9, 6:33 pm, John Harshman <jharshman.diespam...@xxxxxxxxxxx>
wrote:
Evopeach wrote:
On Jan 9, 10:50 am, John Harshman <jharshman.diespam...@xxxxxxxxxxx>
wrote:
Evopeach wrote:
On Jan 9, 3:52 am, stew dean <stewd...@xxxxxxxxx> wrote:
On 8 Jan, 21:55, Evopeach <keaton1...@xxxxxxxxx> wrote:
On Jan 8, 2:52 am, Walter Bushell <pr...@xxxxxxxxx> wrote:
In article
<b12680fb-36c8-4656-9ee9-b2363b9e7...@xxxxxxxxxxxxxxxxxxxxxxxxxxxx>,
Evopeach <keaton1...@xxxxxxxxx> wrote:
So you are positive that there was never a population began by two
sexually reproducing adults. How do you know that?
General knowledge of biology. Not enough genetic difference to be viable.
According to current biological research writ large the total effect
of all error correction during cell replication limits the errors to 1
in 10**10 base pair replications. I have previously referenced
Shapiro on this matter. Thus stasis is the rule and error the
exception.
So we should all be clones of the Noah clan who where in term clones
of Adam and Eve?
Actualy your figures are wrong. It's 10-6 to 10-8 per base pair. From
what I've seen we're talking about 100 differences between you and you
r parents - nearly all which have neutral. That's not much but over
many generations it all adds up, although not enough to get the worlds
diversity even in terms of humans (which are quite similair compared
to other species) based upon an even within even 10,000 years.
Stew Dean- Hide quoted text -
- Show quoted text -
Nope I refer you to the Shapiro presentation I cited with the slides
and RP clip. It's 10**10 the...science moves on.
That wasn't even a sentence. "Mutation rate" by itself doesn't mean
anything without an explanation of just what is being measured. 10^-10
per what? Per genome? Per nucleotide? Per cell division? Per year? Per
generation? That's not too bad an estimate per nucleotide per cell
division, though even this varies quite a bit. But in any multicellular
organism there are many cell divisions per generation, and so a much
greater chance for mutation per generation than the rate you give here.
If the rate you give were applicable directly to humans, the average
person would have zero or one total mutations, rather than the hundred
or so that's observed.
Its DNA replication in a bacterium E. coli actually. Try
reading this.....http://online.itp.ucsb.edu/online/infobio01/shapiro1/
oh/03.html
That's a lengthy slide show. Why not tell me which slide, or perhaps
even quote the slide in full? I suspect the measure you have given is
per site per replication. That's not out of line. Do you understand that
this is not the rate we expect between human generations? There the rate
is about 2.5*10^-8/site/generation, or, given that the human diploid
genome is 6*10^9 bases, roughly 150/genome/generation. This is an
average of male and female rates, since the rate is higher in males; by
far the greatest proportion of mutations in any zygote come from the
male parent.

http://online.itp.ucsb.edu/online/infobio01/shapiro1/oh/03.html

Right. That's mutations/site/replication. So do you understand that this is not the rate we expect between human generations, in which there are many replications per generation?

.

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