Re: 1st D.N.A Replication
- From: John Harshman <jharshman.diespamdie@xxxxxxxxxxx>
- Date: Fri, 17 Feb 2006 22:34:03 GMT
spintronic wrote:
You are confused on several grounds.Same as now.
But are you sure that's your real question? Do you mean how did that 1st
molecule come to be?
Nicholas
Thanks Nicholas. But no thats not my question. The nucleotide's are
floating nitrogenous bases that will randomley bind to each half of the
double helix as the dna strand is split. No probs there. But you have 3
major problems for this process to kick start all on its own.
1) Destructive interference, we see this in cells where the telomers
are shortened and break down, the chromosones just fuse, any old way,
and obviously so would any randomley formindg short helix.
2) The helix length, the chromosones have telomers to protect their
ends from fraying, so no long chain strands could form without the
protection of the telomers.
3) The splitting mechenism, to split the double helix into 2 you need
the help of some complicated proteins and enzymes, If you are assuming
that other mechanisms could seperate the helix your wrong, because if
you start at the ends they are protected by the telomers, if you remove
the telomers the ends fray and snap as you tryt to split the dna.
So youd have to do what happens now, youd have to start in the middle,
and form a bubble by some complicated protein and work outwards.
My question being, since these complicated proteins are in fact
fabricated by the dna splitting process how can you split the first dna
strand to make the first protein?
1. Telomeres are not there for the purpose of "preventing the ends from
fraying". Lots of organisms don't have temomeres, anyway. Many
chromosomes are circular, and have no ends anyway.
2. You can replicate DNA in the lab (using PCR) without any enzymes
other than the DNA polymerase. Heat splits the helix.
3. Early genomes would have been a lot shorter than any chromosome in
the current human genome, and could have been organized into several
chunks, too.
4. None of this is likely to be relevant, as DNA probably arose in a
cell with an RNA genome and proteins already present.
.
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