Re: Coffee 'may reverse Alzheimer's'
- From: Rumpelstiltskin <PleaseDoNotReplyByEmail@xxxxxxxxxxx>
- Date: Mon, 06 Jul 2009 18:46:05 -0700
On Mon, 06 Jul 2009 17:49:41 -0500, Jean Smith <gotermite@xxxxxxxxx>
wrote:
In article <1uOdnRtRi8rNf8zXnZ2dnUVZ_o4AAAAA@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx>,
Jim Higgins <gordian238@xxxxxxxxxxx> wrote:
This means that Dilbert's Wally is the ideal???????????????????????????
Coffee 'may reverse Alzheimer's'
http://news.bbc.co.uk/2/hi/health/8132122.stm
Drinking five cups of coffee a day could reverse memory problems seen
in Alzheimer's disease, US scientists say.
The Florida research, carried out on mice, also suggested caffeine
hampered the production of the protein plaques which are the hallmark of
the disease.
Previous research has also suggested a protective effect from caffeine.
But British experts said the Journal of Alzheimer's disease study did
not mean that dementia patients should start using caffeine supplements.
³ The results are particularly exciting in that a reversal of
pre-existing memory impairment is more difficult to achieve ²
Dr Gary Arendash University of Florida
The 55 mice used in the University of Florida study had been bred to
develop symptoms of Alzheimer's disease.
First the researchers used behavioural tests to confirm the mice were
exhibiting signs of memory impairment when they were aged 18 to 19
months, the equivalent to humans being about 70.
Then they gave half the mice caffeine in their drinking water. The rest
were given plain water.
The mice were given the equivalent of five 8 oz (227 grams) cups of
coffee a day - about 500 milligrams of caffeine.
The researchers say this is the same as is found in two cups of
"specialty" coffees such as lattes or cappuccinos from coffee shops, 14
cups of tea, or 20 soft drinks.
When the mice were tested again after two months, those who were given
the caffeine performed much better on tests measuring their memory and
thinking skills and performed as well as mice of the same age without
dementia.
Those drinking plain water continued to do poorly on the tests.
In addition, the brains of the mice given caffeine showed nearly a 50%
reduction in levels of the beta amyloid protein, which forms destructive
clumps in the brains of dementia patients.
Further tests suggested caffeine affects the production of both the
enzymes needed to produce beta amyloid.
The researchers also suggest that caffeine suppresses inflammatory
changes in the brain that lead to an overabundance of the protein.
Earlier research by the same team had shown younger mice, who had also
been bred to develop Alzheimer's but who were given caffeine in their
early adulthood, were protected against the onset of memory problems.
'Safe drug'
Dr Gary Arendash, who led the latest study, told the BBC: "The results
are particularly exciting in that a reversal of pre-existing memory
impairment is more difficult to achieve.
"They provide evidence that caffeine could be a viable 'treatment' for
established Alzheimer's disease and not simply a protective strategy.
"That's important because caffeine is a safe drug for most people, it
easily enters the brain, and it appears to directly affect the disease
process."
The team now hope to begin human trials of caffeine to see if the mouse
findings are replicated in people.
They do not know if a lower amount of caffeine would be as effective,
but said most people could safely consume the 500 milligrams per day.
However they said people with high blood pressure, and pregnant women,
should limit their daily caffeine intake.
Rebecca Wood, chief executive of the Alzheimer's Research Trust, said:
"In this study on mice with symptoms of Alzheimer's, researchers found
that caffeine boosted their memory. We need to do more research to find
out whether this effect will be seen in people.
"It is too early to say whether drinking coffee or taking caffeine
supplements will help people with Alzheimer's.
Neil Hunt, chief executive of the Alzheimer's Society, said previous
research into caffeine had suggested it could delay Alzheimer's disease
and even protect against vascular dementia.
"This research in mice suggests that coffee may actually reverse some
element of memory impairment.
"However much more research is needed to determine whether drinking
coffee has the same impact in people.
"It is too soon to say whether a cup of coffee is anything more than a
pleasant pick me up."
Quick! Get word to "Teresa" on All Things Considered.
I usually drink two 16-oz mugs of very strong coffee a day, so I'm
covered already. I am a long way from Voltaire, who drank 70.
Those were probably those little dolls-house cups that annoy me
so much, but 70 is a lot even of those. Voltaire had the energy of
a lightning bolt all his days, so I guess it didn't do him any harm.
.
- References:
- Coffee 'may reverse Alzheimer's'
- From: Jim Higgins
- Re: Coffee 'may reverse Alzheimer's'
- From: Jean Smith
- Coffee 'may reverse Alzheimer's'
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