DHEA improves extrapyramidal symptoms
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Fri, 04 Nov 2005 17:21:55 GMT
Schizophr Res. 2005 Nov 15;79(2-3):251-6. Epub 2005 Aug 26.
Improvement of extrapyramidal symptoms following dehydroepiandrosterone
(DHEA) administration in antipsychotic treated schizophrenia patients: A
randomized, double-blind placebo controlled trial.
Nachshoni T, Ebert T, Abramovitch Y, Assael-Amir M, Kotler M, Maayan R,
Weizman A, Strous RD.
Beer Yaakov Mental Health Center, PO Box 1, Beer Yaakov 70350, Israel.
Recent investigation in schizophrenia indicated dehydroepiandrosterone
(DHEA) levels to be inversely correlated with extrapyramidal symptomatology
(EPS). This study thus investigates the effect of DHEA administration on
medication-induced EPS. Inpatients with schizophrenia or schizoaffective
disorder were randomized in double-blind fashion to receive either 100 mg
DHEA or placebo in addition to a constant dosage of antipsychotic
medication. Parkinsonism showed a favorable effect of DHEA with a
significant time effect (p<0.0001), as well as a significant group by time
interaction (p<0.05) and with no change noted on akathisia. Change of DHEA
blood levels was negatively associated with change of Parkinsonism (p<0.05)
as well as with change of total EPS ratings (p<0.05). DHEA appears to
demonstrate a significant effect on EPS, with improvement observed
particularly in Parkinsonian symptoms.
.
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