Re: Anybody been helped by Proscar?
- From: "Pete" <pete@xxxxxxxxxx>
- Date: Sat, 3 Jun 2006 17:30:33 -0400
lawrence@xxxxxxxxxxxxxxxxxxxxx wrote:
root wrote:
My uro has given me a prescription for Proscar but he says itI am on Flomax and Avodart (a newer 5-alpha-reductase inhibitor than
might take over a year to see any benefit. Have any of you
taken Proscar for that duration and seen a benefit? Flomax
has provided an immediate benefit, will that decrease in
time?
TIA
Proscar). My medical oncologist, who specializes in prostate cancer
(I have both prostate cancer and BPH), increased my Avodart dose from
0.5 mg to 1.0 mg because my blood test showed that one capsule did not
sufficiently lower my DHT (worsens prostate cancer at least 4 times
more than testosteerone). It took about 9 months for my Avodart to
help reduce my urinary symptoms. (Avodart was approved by the FDA for
BPH but has an off-label use for slowing prostate cancer growth).
Lawrence...I find this very interesting (regarding the off label use for
slowing prostate cancer growth - since I have read just the opposite for the
sister drug Proscar), and hope Dr. Sancha will comment on this.
Regarding Proscar adverse effects, the following was taken from the
"Essential Guide to Prescription Drugs 2005", by James J. Rybacki, Pharm
D. -
"Higher grade prostate cancer - possible associated higher grade cancers if
a cancer does happen".
"Possible increase in more aggressive tumors if cancer (neoplasm) does
happen - possible".
What is interesting, Rybacki also states that Proscar may help reduce the
risk of prostate cancer by 25%, but apparently you may get a higher grade
cancer if it happens (this is stated in the lead in "benefits vs. risks
table" for Proscar. This is kind of confusing at best, and I asked one of
my uro's about this once, and got bullshit back (he didn't know or some
horse shit like that).
Could you please list a reference(s) that state the off label use for
Avodart slowing prostate cancer growth. I checked the package insert and
also did a quick google search and came up empty. If it is something your
oncologist told you, I would be interested where he got the data from.
Dr. Sancha if you are reading this, please comment. Thanks...Pete
My urologist, after two years, increased my dose of Flomax (an alpha
blocker) from 0.4 to 0.8 mg, in an effort to improve my BPH symptoms,
which were worsening.
Being on both Avodart and Flomax eased my urinary problems about 2
years ago. A 2002 study showed that taking both Proscar and the alpha
blocker doxazosin (Cardura) was more effective than either drug alone.
Research has found that Proscar was most effective in men with large
prostates and with PSAs of 1.4 or higher.
For more info about BPH, go to a new BPH website,
http://www.ljblgb.com/index.htm
Lawrence J. Bookbinder
.
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