Re: eflornithine compounding

Should have paid more attention during your pharmaceutics class...

Okay, all joking aside... the polarity of a drug and its vehicle is very
often opposite to maximize drug release from the vehicle. Imagine: if
the drug is highly soluble (or miscible) in its vehicle relative to the
surrounding body fluid, the drug will preferentially remain in the
vehicle and release will be poor.

Also note that in the case eflornithine, it is an amino acid derivative
with an additional ionizable sidechain, so its aqueous solubility will
be strongly dependent on pH. With a suitable choice of buffer or
cosolvent, you can probably cause it to incorporate equally well into a
hydrophobic or hydrophilic vehicle.

Good luck.


paolo wrote:

hi,

does anybody know why eflornithine is incorporated in a lipophil cream
(vaniqa) even if the substance is soluble in water? is there any problem in
topic absorption if i incorporate it in an hydrophil cream?
of course there's no blood absorption thus it should work in the upper
layers of the skin...

thanks for any help and sorry for my bad translation.

Paolo
.

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