Why Infections may be Increasing with Human Populations
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Sat, 19 Aug 2006 10:00:14 -0500
Why Infections may be Increasing with Human Populations
Copyright 2006, James Michael Howard, Fayetteville, Arkansas, U.S.A.
The increase in MRSA infections may be explained (N Eng J Med. 2006 Aug
17;355(7):666-74). It is my hypothesis that the ?secular trend,? the
increase in size and earlier puberty of children, may be caused by an
increase in the percentage of women of higher testosterone within the
population over time. It is also my hypothesis that testosterone increases
use of DHEA by tissues because of increased androgen receptors as a result
of exposure to increased maternal testosterone in utero. I suggest the
increase in MRSA and other infectious agents, such as the HIV, are
increasing in the population as a result of the secular trend, especially
among groups of high testosterone.
I suggest infections stimulate release of DHEA. If this release is too
high, as might occur in high testosterone individuals, it causes problems
with T cells. HIV infection is known to trigger a very large increase in
DHEA and that T cell decline in AIDS. It has been demonstrated that ?High
doses of DHEA significantly inhibited proliferation of peripheral blood
mononuclear cells and T cells induced by T cell mitogens hemagglutinin and
concanavalin A.? (J Steroid Biochem Mol Biol 2006; 99: 115-20). This may
explain why T cells decline in AIDS / HIV. (It is my hypothesis that all
of the symptoms of AIDS result from loss of DHEA.) Men and blacks produce
more testosterone than whites and AIDS has just recently been labeled a
?black disease? in America.
It has also been determined that vancomycin MIC is increased in MSSA
(methicillin-sensitive S. aureus) and MRSA (methicillin-resistant S.
aureus) are increased by DHEA, ?only in the presence of DHEA, and was not
related to altered generation time, indicating induction of phenotypic
resistance.? (Lett Appl Microbiol 2005; 40: 249=54). ?S. aureus expresses
exotoxins with biological properties of superantigens that induce T-cell
activation with subsequent anergy and immunosuppression.? (J Dermatol Sci
2006; 42: 203-14). This all may be due to an exaggerated DHEA response to
infections.
I suggest the increase in numerous infections within human populations is
caused by an increase of the percentage of women of higher testosterone
within the population with time. This increases androgen receptors in
children which is causing both acute and long term problems as a result of
sudden, excess DHEA and earlier arrival at the natural decline of DHEA
production around age twenty to twenty-five years of age.
.
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