Re: Protective Autoimmunity

"Kumar" <lordshiva5753@xxxxxxxxx> wrote in message
news:1db494a4-68a4-42c1-9c4d-5d4f97ab05b1@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
On Mar 2, 11:00 am, "John Hasenkam" <jo...@xxxxxxxxxxxxxxxx> wrote:
Yes, there was a J of Neuroscience study which highlighted how autoimmune
processes were protective in secondary injury. Generally though,
inhibiting
immune responses appears beneficial with the initial injury.

John.

The Journal of Neuroscience, July 1, 2001, 21(13):4564-4571

Neuronal Survival after CNS Insult Is Determined

by a Genetically Encoded Autoimmune Response

Jonathan Kipnis, Eti Yoles, Hadas Schori, Ehud Hauben, Iftach Shaked, and

Michal Schwartz

Department of Neurobiology, The Weizmann Institute of Science, 76100
Rehovot,

Israel

Injury to the CNS is often followed by a spread of damage (secondary
degeneration), resulting in neuronal losses that are

substantially greater than might have been predicted from the severity of
the primary insult. Studies in our laboratory have shown

that injured CNS neurons can benefit from active or passive immunization
with CNS myelin-associated antigens. The fact that

autoimmune T-cells can be both beneficial and destructive, taken together
with the established phenomenon of genetic

predisposition to autoimmune diseases, raises the question: will genetic
predisposition to autoimmune diseases affect the

outcome of traumatic insult to the CNS?
Hello,

Can you tell me about protective autoimmunity in case of damage to CNS
due to spinal injury at C5 level?

Can immune or autoimmune response be beneficial in these cases?

Best wishes.- Hide quoted text -

- Show quoted text -

Thanks a lot. Actually I also tried by reading such type of studies.
Does it suggest that, on initial injury to CNS, active immune system
can cause greater damage than real insult? Glial scar formation can be
important outcome from such immune response or from medication
programme. It may be difficult to reverse formed glial scars after
insult, basic importance can be that, 1. scars are not formed at
initial stage of insult to CNS 2. if formed, how it can be removed
enabling nerve regenaration. Can initial immune response inhibit glial
scar formation and can autoimmune response remove formed glial scars
at some time after insult to encourage nerve regeneration?

This understanding looks to be quite important for understanding
natural or mediacated recovery to CNS injuries.

Btw, how many people recover on its own after some time of initial
insult to CNS injury of C5 level?
-----

Generally suppression of the immune response appears to confer benefit.
It *may* be possible to prevent glial scar formation via inhibition of
chondroitin sulfate, I recall one study which demonstrated that. I doubt it
will be that simple.
Reversal of glial scars is highly unlikely.
You are correct, this is very important in regards to CNS injury but we are
a long way from clinical applications.
We do not know how many people recover from CNS injury. Rates of recovery
vary quite a bit.


.

Relevant Pages

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