Re: Protective Autoimmunity
- From: "John Hasenkam" <johnh@xxxxxxxxxxxxxxxx>
- Date: Tue, 3 Mar 2009 10:27:10 +1000
"Kumar" <lordshiva5753@xxxxxxxxx> wrote in message
On Mar 2, 11:00 am, "John Hasenkam" <jo...@xxxxxxxxxxxxxxxx> wrote:
Yes, there was a J of Neuroscience study which highlighted how autoimmune
processes were protective in secondary injury. Generally though,
immune responses appears beneficial with the initial injury.
The Journal of Neuroscience, July 1, 2001, 21(13):4564-4571
Neuronal Survival after CNS Insult Is Determined
by a Genetically Encoded Autoimmune Response
Jonathan Kipnis, Eti Yoles, Hadas Schori, Ehud Hauben, Iftach Shaked, and
Department of Neurobiology, The Weizmann Institute of Science, 76100
Injury to the CNS is often followed by a spread of damage (secondary
degeneration), resulting in neuronal losses that are
substantially greater than might have been predicted from the severity of
the primary insult. Studies in our laboratory have shown
that injured CNS neurons can benefit from active or passive immunization
with CNS myelin-associated antigens. The fact that
autoimmune T-cells can be both beneficial and destructive, taken together
with the established phenomenon of genetic
predisposition to autoimmune diseases, raises the question: will genetic
predisposition to autoimmune diseases affect the
outcome of traumatic insult to the CNS?
Can you tell me about protective autoimmunity in case of damage to CNS
due to spinal injury at C5 level?
Can immune or autoimmune response be beneficial in these cases?
Best wishes.- Hide quoted text -
- Show quoted text -
Thanks a lot. Actually I also tried by reading such type of studies.
Does it suggest that, on initial injury to CNS, active immune system
can cause greater damage than real insult? Glial scar formation can be
important outcome from such immune response or from medication
programme. It may be difficult to reverse formed glial scars after
insult, basic importance can be that, 1. scars are not formed at
initial stage of insult to CNS 2. if formed, how it can be removed
enabling nerve regenaration. Can initial immune response inhibit glial
scar formation and can autoimmune response remove formed glial scars
at some time after insult to encourage nerve regeneration?
This understanding looks to be quite important for understanding
natural or mediacated recovery to CNS injuries.
Btw, how many people recover on its own after some time of initial
insult to CNS injury of C5 level?
Generally suppression of the immune response appears to confer benefit.
It *may* be possible to prevent glial scar formation via inhibition of
chondroitin sulfate, I recall one study which demonstrated that. I doubt it
will be that simple.
Reversal of glial scars is highly unlikely.
You are correct, this is very important in regards to CNS injury but we are
a long way from clinical applications.
We do not know how many people recover from CNS injury. Rates of recovery
vary quite a bit.
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