Re: Acid, Base, Water & Temp. Balances?


Bryan Heit wrote:
> kumar wrote:
> > Bryan Heit wrote:
> >>Basically, restored oxygen flow activates
> >>your immune cells, which then begin to produce damaging chemicals
> >>(including oxidants). This results in increased damage to the ischemic
> >>tissues.
> >
> > Can the cause of this damage be acidosis or lactic acidosis at the site
> > of damage? Starving a tissue of Oxygen can encourage lactic acid
> > production.
>
>
> Some of the damage is due to acidosis of the tissue, particularly when
> the tissue is starved for oxygen over a long period of time (i.e. a
> transplanted organ). However, the damage caused by oxidant production
> tends to be the predominant form of damage. Keep in mind that it only
> takes a short period of time after blood flow is restored to eliminate
> acidosis. Oxidant production (and other damaging aspects of
> inflammation) can last for hours, or even days.

Can't oxidants production release hydrogen ions resulting into pH
changes?
>
>
> > Let us check immunological side. Hill stations or higher altitudes are
> > considered to improve immunity. Will it be by pure air or less O2 at
> > higher altitude?
>
>
> I don't think this is correct. I am unaware of any study showing
> significant differences in immunity due solely to differences in
> altitude. Keep in mind that your body is remarkable able to adapt to
> changes in the environment - including differences in altitude. If you
> live for a time at increased altitude your body will adapt by increasing
> production of hemoglobin and red blood cell production. People who grow
> up at high altitudes will even develop "barrel chests"; which is a
> result of over development of lung size due to continued low oxygen
> partial pressures.
Adaption to any condition may be a long term effect. What about short
term effect on shifiting from lower altitude to higher one?

Not sure but it is indicative that on getting any chronic disease esp.
dormant/latent type disease as latent infections, cancer, autoimmunity
etc., iron/blood supply to the dormant site is discouraged to starve
the causing agents(esp indicative by firey red(not deep red) tongue and
lips). Probably, it also trigger the lesser absorption of iron or B12.
Probably getting anemia iron or B12/folic acid based may sometimes be a
positive defence response.

Under this consideration, an decrease in O2 levels or iron level as on
higher altitude trigger more immune response? Does lower O2 level
encourge more immune response or starve infecting/disease causing
agents?
> > Anyway, can imbalance in any place of iron effect imbalance in fats
> > oxidation or its accumulation?
>
>
> A lack of iron causes several problem, almost all related to lack of
> oxygen movement through the body. One of the first problems associated
> with iron deficiency is anemia; a lack of red blood cells (or RBC's
> without sufficient hemoglobin). Mild anemia is associated with a
> continued feeling of tiredness and weakness (due to insufficient oxygen
> making it to your tissues). As iron levels drop further the anemia
> becomes more acute. Eventually this can reach a point where the patient
> becomes wasted, and more susceptible to infection. AFAIK this poor
> immunity and wasting is still due to a lack of oxygen in the blood,
> rather then defects in other metabolic pathways.
>
> Interestingly, many vegetarians suffer from mild anemia due to a lack of
> iron and other minerals normally ingested via meat consumption.

As per last reply. How can we differenciate between real defficiency,
real excesses and imbalances(more at one part less at other--still
blood level in normal) in iron level in body?
>
> > What about role of iron in heat
> > production on excess oxidation of fats? I feel iron can cause both
> > heating and cooling effects to body. ??
>
>
> The heat our bodies generate is a product of our metabolism. Some of
> these enzyme do contain iron, so in that context our body temperature is
> due, in part, to iron. Iron wouldn't play a role in cooling; our bodies
> cool themselves via sweating, not by reducing the basal metabolic rate
> (this is determined largely by our bodies energy demands).
>
> As for fat, it's "warming" effect is due to its insulatory effect.
> Unlike some animals (rodents, for example), humans don't have "brown
> fat", which is a specialized type of fat which generates heat. As such
> any warming we get from fat is due to the fact that fat acts like
> insulation, and lowers the rate that heat leaves our body.

I think oxidation of fats may provide immediate heat but cooling(normal
temp. afterwords which was persistently higher due to insulation) after
oxidation. Ok?
Does fats deposition in testis or in other part of body due to any
disorder to provide insulation or heat to that part as by injury?

> > Btw, what factors weakens or strengthen the immunity?
>
> Wow, there's a loaded question. The answer is "probably everything".
> Nearly everything you do, nearly every disease you get, every food you
> eat, every drug you use, has the potential to impact on your immune
> system to some extent. Some of these have very predictable effects,
> while the effects of others will depend on the individual.
>
In view of new immune cells are always produced from stem cells except
some B cells, how it become possible? Where strength of immunity lies?
I think it can't be in stem cells as genetic form remains the same. We
discussed it in "resistances by conventional medicines topic.
> > Somewhere it is indicated that heat is produced due to fat deposits and
> > by their excess oxidations, but still it is unclear. Can fats be
> > imbalanced in cells membranes as lipo-protien or lipofusion deposits?
>
> Not really. There is a big difference between the chemical structure of
> fat, and the lipids which make up our membranes. Generally speaking,
> the types of molecules found in body fat are not found within our cell
> membranes. That said, changes in membrane lipid makeup can drastically
> alter then characteristics of cells. There are probably diseases
> related to this, but I don't know what they are off hand.
>
> Bryan

Thanks.

.

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