Re: 'nother Fosamax question


> The original insert information indicated that x% was absorbed within the
> first half-hour, y% was absorbed within the first hour and, if I recall,
> z% was
> absorbed within the first one and one-half hours, with increasing
> percentages
> each time.
>
> Right now all I see is that women absorb 64% if taken two hours before
> eating
> while men absorb 59% but, if women eat between one-half and one hour after
> taking Fosamax, the bioavailability is reduced by 40%.
>
> Art
>
>Since they have changed the time to eat or drink from 1 hour to 1/2 hour
>(from the original insert), I wonder if they have changed these
>percentages. I don't eat for a couple of hours, but wait about 45 minutes
>for that first sip of coffee.

Why do I dislike these companies? In the insert I quote:" A study
examining the effect of timing of a meal on the bioavailability of
alendronate was performed in 49 postmenopausal women. . . . . . ." The
insert is for 70mg. The study is done on 10mg. Don't they have enough
money to repeat the study on about 500 women, and use the 70 mg? I don't
want to read any more of that insert, but whatever there is should be clear.
That insert is not clear. Also how do you study a live person's bone to see
what the dose of a product is doing and if it is doing it within 30 minutes
instead of an hour? Let's see, if they studied 49 women, then half should
be the control group. Therefore 25 had the med, and 25 didn't. Of the 25
being really tested, what were they doing - were they sitting, walking,
smoking, etc. Post menopausal could be from ages 50 - 100. This is very
silly. I am missing something here.

Sammy


.

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