A Broader Picture of Type 2 Diabetes with Newer Technology

Researchers have been looking more in depth and breadth of the disease called type 2 diabetes. Using global gene expression analysis microarrays of placed on gene chips can be used to indentify the areas in which diabetes changes genes involved in numerous aspects of biochemistry, molecular biology, physiology, etc. This is an outcome of the genome project of several years back and is now being applied to specific diseases. This is basic research that will eventually be extended to the individual at the clinical level so that the causes of pathological gene expression, for instance, insulin resistance, can be narrowed down to a group of genes and therapies designed to fit a person's situation. Computers can be used to setup parameters of the normal physiology as well as the pathological outliers that result in disease. By looking at the gene expression in offspring of type 2 diabetics some of the genetic aspects can be separated from the environmental aspects of T2 and set the stage for prevention in the offspring.

A scholar.google.com search for Probe+Set+ID+human+diabetes+lipid resulted in 6880 finds - http://tinyurl.com/2qck9f. The first reference listed is "Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases Expression of Extracellular Matrix Genes in Human Skeletal Muscle" - A Journal of Biochemistry article.

Probe+Set+ID+human+"type 2"+diabetes+lipid+carbohydrate+metabolism, 651 finds - http://tinyurl.com/39yez7

Probe+Set+ID+human+"type 2"+diabetes+lipid+carbohydrate+metabolism+ "insulin resistance", 268 finds - http://tinyurl.com/2hvq44.

Some of these finds do not apply the microarray technology, yet some of the subsequent citions of the articles do - Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects - http://diabetes.diabetesjournals.org/cgi/content/abstract/56/4/992

DAVID Bioinformatics Resources:
The Database for Annotation, Visualization and Integrated Discovery (DAVID) 2007 is an expanded version of our original web-accessible programs of DAVID 2006, 2.1, 2.0 & 1.0. DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes - http://david.abcc.ncifcrf.gov/

Frank
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Relevant Pages

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  • Research into Diabetes Genes was Re: Thanks for being here
    ... Actually, it isn't at all speculative, but has been investigated and is known to be true in those forms of genetic diabetes where a gene is clearly implicated. ... In these forms of diabetes, gestational diabetes is always present in a female carrier, no matter what her blood sugar status before pregnancy. ... The explanation for the more severe diabetes in the offspring of female carriers is that gestational diabetes creates an environment in the womb that affects the gene expression. ...
    (alt.support.diabetes)
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