Re: Insulin related?


kumar wrote in message
<1138521433.438635.39910@xxxxxxxxxxxxxxxxxxxxxxxxxxxx>...
>
>>
>I think its form is depending on concentration and pH...means different
>concentrations and pH can cause different forms. It can also depend
>upon presence of zinc. . . .
.
>

>I think short acting inulin is supplied as mono/dimers. It is also said
>that insulin is not polymerized/aggragated as hexamer in blood.
>. . . .

>Can there be any other resistance than fats layer to insulin's
>absorption/transport into blood?
>
>Can't endogenous insuin after secreted in blood be stored at any part
>of body?

Whether or not insulin monomers can form hexamers does depend on pH and
is facilitated by the presence of zinc. However,

a. At body pH and vial pH, the pH condition is satisfied (pH 2 -
8)

b. Both self-manufactured and injected human insulins are supplied
with zinc at all times in the beta cells and vials

Short acting insulins are modified so as to not form hexamers. That is why
they are short acting. All insulins are present at such dilute
concentrations in blood that they cannot maintain an oligomer structure,
i.e. they are almost always present as monomer.

Injected insulin must diffuse through fat to reach a capillary, then
through the capillary wall to reach the blood. Diffusion is always a slow
process when compared to other chemical and physical processes.

I have read a citationg which asserted that a small portion of endogenous
insulin is temporarily removed from the blood circulating through the liver
and stored for near-future release as sort of a buffer supply. I have only
seen this assertion once. It may be an example of fuzzy writing.

Regards
Old Al


.

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