Re: I was just thinking.....diabetes related - 1 attachment

I don't claim to understand the mechanisms other than in a general
way. I'll give you a short quote from LeRoith and a couple references
it cites which should be plenty to start chasing the answer. Note in
this paragraph, they are talking about normals.

Quote:
Insulin plays a key role in the regulation of metabolic fuel delivery
and utilization during exercise. Its secretion is suppressed during
physical activity in response to alpha-adrenegic inhibitory effects on
the pancreatic beta-cells. In addition, increased blood flow to
working muscles results in increased insulin delivery to these
tissues. The falling insulin concentration in plasma has major
effects on glucose, lipid, and amino acid metabolism, making these
fuels more readily available for energy production. Insulin is the
major inhibitor of hepatic glucose production, and the fall in plasma
insulin concentration during exercise, coupled with no change or a
rise in plasma glucagon concentration, results in increased hepatic
glucose output. This is closely correlated with peripheral glucose
utilization and maintenance of blood glucose concentration within a
normal range. In addition, the falling insulin concentration
decreases the inhibitory effects on lipolysis in adipose tissue and
the release of amino acids from muscles. Since little or no insulin
is needed for glucose uptake in exercising muscle (35), the fall in
plasma insulin concentration does not impair glucose utilization
during exercise.
End Quote

32. Galbo H. Hormonal and metabolic adaption to exercise. New York:
Thieme Stration, 1983.
33. Sutton JR, Farrell PA. Endocrine responses to prolonged exercise.
In: Lamb DR, Murray R, eds. Perspectives in exercise science and
sports medicine, vol 1: prolonged exercise. Indianapolis: Benchmark
Press, 1988:153
35. Richter EA, Ploug T, Galbo H. Increased muscle glucose uptake
following exercise: no need for insulin during exercise. Diabetes
1985;34:1041

--
-------
Charly Coughran
ccoughran@xxxxxxxxxxxxxxxxxxxxxxxxxx



"Buhda" <akhanna@xxxxxxxxxxxxxx> wrote in
news:%KvHe.92796$X76.49473@xxxxxxxxxxxxxxxxxxxx:

> "When a normal person starts to exercise, the insulin output of his
> pancreas goes down. At first blush, this seems backward since the
> muscles are working hard and therefore require more glucose to be
> transported from the blood into the cells. There are two reasons
> more glucose can be transported with less available insulin. The
> first is that during exercise insulin becomes much more efficient.
> The mechanism of this effect is not fully understood, but it helps
> overcomes the reduction in circulating insulin.
>
> Second, exercise activates non-insulin mediated glucose transport
> pathways. These pathways are not sufficient to handle the load in
> the absence of insulin, but do increase the effective insulin
> efficiency."
>
>
> This is what I am talking about....there is something that activates
> the 2ndary pathways of transport....hopefully it is a molecule (or
> protien or enzyme) and NOT the absence of insulin. So someone could
> figue out what that molecule is and find a way to activate those
> pathways when exerscise has not been done ( or done at some other
> time).
>
>
>
> "Charly Coughran" <ccoughran@xxxxxxxxxxxxxxxxxxxxxxxxx> wrote in
> message news:Xns96A55D3E5189ccoughranucsdedu@xxxxxxxxxxxxxxxx
>> "Buhda" <akhanna@xxxxxxxxxxxxxx> wrote in
>> news:96cHe.45625$0f.38375@xxxxxxxxxxxxxxxxxxxx:
>>
>>> When I workout (lift weights) and test my BG after it is usually
>>> very low (for me). Lower than even my fasting BG. Now if I
>>> understand T2 correctly either I'm not making enough Insulin or my
>>> cells don;t recognize the insulin optimaly. But after working out
>>> there is some mechanism that makes cells hyper-sensitive to the
>>> insulin. Is there any research being done into this mechanism????
>>>
>>>
>> Attached is an explanation of some of the things that go on during
>> exercise. It is written from the viewpoint of type 1s, but has an
>> explanation of the counterintuitive response of insulin to
>> exercise.
>>
>>
>> --
>> -------
>> Charly Coughran
>> ccoughran@xxxxxxxxxxxxxxxxxxxxxxxxxx
>>
>>
>
>
>

.

Relevant Pages

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