Astragalus

Astragalus
Also listed as: Astragalus membranaceus; Astragalus mongholicus; Huang-
qi; Milk-vetch root

Overview
Plant Description
Parts Used
Medicinal Uses and Indications
Available Forms
How to Take It
Precautions
Possible Interactions
Supporting Research


Overview
Astragalus ( Astragalus membranaceus) has been used in Traditional
Chinese Medicine for thousands of years, often in combination with
other herbs, to strengthen the body against disease. It contains
antioxidants, which protect cells against damage caused by free
radicals, byproducts of cellular energy. Astragalus is used to protect
and support the immune system, for preventing colds and upper
respiratory infections, to lower blood pressure, to treat diabetes,
and to protect the liver.

Astragalus has antibacterial, anti-inflammatory, and diuretic (helps
eliminate fluid from the body) properties. It is sometimes used
topically for wounds. In addition, studies have shown that astragalus
has antiviral properties and stimulates the immune system, suggesting
that it is indeed effective at preventing colds.

In the United States, researchers have investigated astragalus as a
possible treatment for people whose immune systems have been
compromised by chemotherapy or radiation. In these studies, astragalus
supplements have been shown to speed recovery and extend life
expectancy. Research on using astragalus for people with AIDS has
produced inconclusive results.

Recent research in China indicates that astragalus may offer
antioxidant benefits to people with severe forms of heart disease,
relieving symptoms and improving heart function. At low to moderate
doses, astragalus has few side effects, although it does interact with
a number of other herbs and prescription medications.



Plant Description
Astragalus is a perennial plant, about 16 - 36 inches tall, that is
native to the northern and eastern parts of China as well as Mongolia
and Korea. It has hairy stems with leaves made up of 12 - 18 pairs of
leaflets. The root is the medicinal part, and is usually harvested
from 4-year-old plants.



Parts Used
The dried root is used medicinally.



Medicinal Uses and Indications
Traditional uses include the treatment of the following:

Colds and influenza
Persistent infection
Fever
Multiple allergies
Asthma
Chronic fatigue
Fatigue or lack of appetite associated with chemotherapy
Anemia
Wounds
Heart disease
Kidney disease
Hepatitis
Stomach ulcers
It is also used to treat general digestive disturbances, including
diarrhea, gas, and bloating.



Available Forms
Astragalus root may be available in a variety of forms:

Tincture (liquid alcohol extract)
Capsules
Injectable forms for use in hospital or clinical settings
Ointments for the skin


How to Take It
Pediatric

Astragalus may be given to children to support the immune system but
should not be used if the child has a fever because, according to
Traditional Chinese Medicine, it may make the fever last longer or
grow stronger. The dose should be determined by adjusting the
recommended adult dose to account for the child's weight. Most herbal
dosages for adults are calculated on the basis of a 150 lb (70 kg)
adult. Therefore, if the child weighs 50 lb (20 - 25 kg), the
appropriate dose of astragalus would be 1/3 of the adult dosage.
However, because strengths and concentrations will vary with different
preparations, dosages should be determined on an individual basis. Any
long-term dosage should be determined by your doctor.

Adult

Doses from 1 - 25 g per day are sometimes used. Higher doses may
suppress the immune system. Recommended doses are as follows:

Decoction (strong boiled tea): 3 - 6 g of dried root per 12 oz water,
three times per day
Fluid extract (1:1) in 25% ethanol: 2 - 4 mL three times a day
Powdered root: 500 - 1,000 mg three or four times per day
Powdered extract (solid): 100 to 150 mg of a product standardized to
0.5% 4-hydroxy-3-methoxy isoflavone. Note : this chemical is used only
as a manufacturing marker, not as a guarantee of potency or
effectiveness.
Ointment: 10% astragalus applied to surface of wound. Do not apply to
open wound without your doctor's supervision.
Tincture (1:5) in 30% ethanol: 3 - 5 mL three times a day


Precautions
At recommended doses, astragalus has no serious side effects and can
generally be used safely. It does interact with other herbs and
medications (see " Possible Interactions ")

If you are pregnant or breastfeeding, you should talk to your doctor
before taking any medication, including herbs.



Possible Interactions
If you are being treated with any of the following medications, you
should not use astragalus without first talking to your health care
provider:

Antiviral medications -- Astragalus may increase the effects of some
antiviral medications such as acyclovir and interferon.

Drugs that suppress the immune system -- Astragalus may counteract the
immune-suppressing effects of cyclophosphamide, a medication used to
reduce the chances of rejection in transplant recipients, as well as
corticosteroids.

Diabetes medications -- Astragalus may lower blood sugar, making the
effects of diabetes drugs stronger.

High blood pressure medication -- Astragalus may lower blood pressure,
making the effects of these drugs stronger.

Diuretics (water pills) -- Astragalus is a diuretic and may make the
effects of other diuretics stronger.

Anti-coagulants(blood thinners) -- Astragalus may make the effects of
these drugs stronger, increasing the risk of bleeding and stroke.



Supporting Research
Brush J, Mendenhall E, Guggenheim A, Chan T, Connelly E, Soumyanath A,
Buresh R, Barrett R, Zwickey H. The effect of Echinacea purpurea,
Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and
immune cell activation in humans. Phytother Res . 2006 Aug;20(8):
687-95.

Chen LX, Liao JZ, Guo WQ. Effects of Astragalus membranaceus on left
ventricular function and oxygen free radical in acute myocardial
infarction patients and mechanism of its cardiotonic action [in
Chinese]. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995;15(3):
141-143.

Chevallier A. The Encyclopedia of Medicinal Plants. New York, NY: DK
Publishing; 1996.

Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal
herbs. I. Immune restoration of local xenogeneic graft-versus-host
reaction in cancer patients by fractionated Astragalus membranaceus in
vitro. J Clin Lab Immunol . 1988a;25(3):119-123.

Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal
herbs. II. Reversal of cyclophosphamide-induced immune suppression by
administration of fractionated Astragalus membranaceus in vivo. J Clin
Lab Immunol . 1988b;25(3):125-129.

Huang KC. The Pharmacology of Chinese Herbs . 2nd ed. New York, NY:
CRC Press; 1999.

Khoo KS, Ang PT. Extract of Astragalus membranaceus and Ligustrum
lucidum does not prevent cyclophosphamide-induced myelosuppression.
Singapore Med J . 1995;36:387-390.

Kurashige A, Akuzawa Y, Endo F. Effects of astragali radix extract on
carcinogenesis, cytokine production, and cytotoxicity in mice treated
with a carcinogen, N-butyl-N¢-butanolnitrosoamine. Cancer Invest .
1999;17(1):30-35.

Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of
ischemic heart disease with Astragalus membranaceus [in Chinese].
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih . 1995;15(2):77-80.

Li XY. Immunomodulating Chinese herbal medicines. Mem Inst Oswaldo
Cruz . 1991;86(suppl 2):159-164.

Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of
Astragalus membranaceus on sodium and water retention in experimental
heart failure. Chin Med J (Engl). 1998;111(1):17-23.

McGuffin M, Hobbs C, Upton R, eds. American Herbal Products
Association's Botanical Safety Handbook . Boca Raton, Fla: CRC Press;
1997.

Miller L, Murray W, eds. Herbal Medicinals: A Clinician's Guide. New
York, NY: Pharmaceutical Products Press; 1998.

Peng T, Yang Y, Riesemann H, Kandolf R. The inhibitory effect of
Astragalus membranaceus on coxsackie B-3 virus RNA replication. Chin
Med Sci J. 1995;10(3):146-150.

Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some
traditional chinese medicinal herbs: a review. Curr Med Chem . 2004
Jun;11(11):1423-30.

Upton R. American Herbal Pharmacopoeia and Therapeutic Compendium --
Astragalus Root . Santa Cruz, Calif: American Herbal Pharmacopoeia;
1999.

Wagner H, Bauer R, Xiao P, Chen J, Offerman F. Chinese drug monographs
and analysis -- Radix Astragali (Huang Qi). Verlag Fur Ganzheitliche
Medizin . 1996;1(8).

Wang LX, Han ZW. The effect of Astragalus polysaccharide on endotoxin-
induced toxicity in mice [in Chinese]. Yao Hsueh Hsueh Pao .
1992;27(1):5-9.

White L, Mavor S. Kids, Herbs, Health . Loveland, Colo: Interweave
Press; 1998: 22, 25.

Wu Y, Ou-Yang JP, Wu K, Wang Y, Zhou YF, Wen CY. Hypoglycemic effect
of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol
Sin. 2005 Mar;26(3):345-52.

Yu DH, Bao YM, Wei CL, An LJ. Studies of chemical constituents and
their antioxidant activities from Astragalus mongholicus Bunge. Biomed
Environ Sci. 2005 Oct;18(5):297-301.

Zhang WD, Zhang C, Wang XH, Gao PJ, Zhu DL, Chen H, Liu RH, Li HL.
Astragaloside IV dilates aortic vessels from normal and spontaneously
hypertensive rats through endothelium-dependent and endothelium-
independent ways. Planta Med . 2006 Jun;72(7):621-6.



Review Date: 1/7/2007
Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing
in complementary and alternative medicine, Phoenix, AZ. Review
provided by VeriMed Healthcare Network.
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