HPV Vaccine, Cervarix™, not Therapeutic in Women with Preexisting Infection
- From: Myrl <wisgroup_leader@xxxxxxxxx>
- Date: Sun, 20 Apr 2008 11:03:22 -0700 (PDT)
As a mother of three daughters and 3 grand-daughters, I have
particular interest in the vaccines which can prevent HPV and upward
of 70% of Cervical Cancers.
I am also a Cervical Cancer survivor. My mother died from Cervical
Uterine Cancer.
I began my exploration of information on these vaccines in a negative
thought process, because I'm not especially filled with trust when it
comes to the FDA and pharmaseudical companies.
However, I am a health consummer, as I believe most folks are. We
ideally should want for the best information regarding any health
regimines and treatments available to us.
It is in that perspective, that I have come to endorse vaccines which
prevent HPV.
Myrl
HPV Vaccine, Cervarix™, not Therapeutic in Women with Preexisting
Infection
Researchers affiliated with the Costa Rican HPV Vaccine Trial have
reported that women who are positive for HPV DNA, do not benefit from
Cervarix (GlaxoSmithKline) a vaccine against HPV 16/18 L1 virus-like
particle. The details of this study appeared in the August 15, 2007
issue of the Journal of the AmericanMedical Association.[1]
HPV is the sole cause of cervical cancer, and types 16 and 18 are the
most common. The seven most prevalent types of HPV cause almost 90% of
all cases of cervical cancer while types 16 and 18 are the cause of
approximately 70% of all cases. Cervical cancer can occur from 2 to 50
years after the onset of infection. Over 20 million Americans are
infected with some type of HPV virus. In most developing countries,
most women are already infected with HPV making development of a
vaccine paramount in controlling this disease. It is also important to
point out that HPV is associated with infections and cancers of other
sites such as the vulva, vagina, anus, penis and oropharynx. It is
anticipated that vaccines against cervical HPV would also be effective
for HPV infections in sites other than the cervix.
Cervarix is 90.4% effective in preventing cervical intraepithelial
neoplasia (CIN) 2+ related to HPV 16/18 in previously unexposed women.
Gardasil®, a quadravalent vaccine against HPV types 6/11/16/18 (Merck)
has been approved by the US Food and Drug Administration for
vaccination of young girls and women. Most studies of Cervarix and
Gardasil have shown that vaccination has little impact on infected
women. This is the reason vaccination is recommended for young girls
before sexual exposure.
In the present study, there was no evidence of increased viral
clearance at 6 or 12 months in women between the ages of 18 and 26 who
had HPV DNA. The researchers observed clearance of HPV-16/18 in 33.4%
of the vaccine group and 31.6% of the control group at six months.
Clearance was observed at 12 months in 49% of the vaccine group and
50% of the control group.
Comments: An accompanying editorial emphasizes the fact than HPV
vaccines have diminished effectiveness with age as most infections are
acquired at an early age. These authors also mentioned that Gardasil
is being tested in males.[2]
References:
[1] Hildesheim A, Herrero R, Wacholder S, et al. Effect of human
papillomavirus 16/18 L1 viruslike particle vaccine among young women
with preexisting infection. Journal of the American Medical
Association 2007;298:743-753.
[2] HPV vaccines – Prophylactic, not therapeutic. Journal of the
American Medical Association 2007; 298:805-806.
http://professional.cancerconsultants.com/oncology_main_news.aspx?id=40365
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