More Dangerous Irresponsible Advice From The Blogspot SPAMMER
- From: Mark Thorson <nospam@xxxxxxxxx>
- Date: Tue, 18 Sep 2007 13:16:48 -0700
Dave wrote:
Many people have found that adapatogens can be
taken instead of prescription antidepressants,
or along with the pharmaceuticals at
reduced levels.
That's dangerous, irresponsible advice.
The most famous adaptogen, ginseng, contains
a powerful inhibitor of the main drug efflux
transporter, P-glycoprotein. This will
affect the titration of dose for people on
antidepressant drugs. These people must
not simultaneously self-medicate with an
uncontrolled dose of an herb that affects
drug clearance from the human body.
But the spammer will never tell you that,
because it would hurt supplement sales.
The spammer won't say anything that might
offend the supplement companies he wants
to have as sponsors of his commercial
blogspot web site.
You'll never get complete information from
the blogspot spammer. He will only tell
you the parts which support supplement sales,
not the whole picture. He just wants to get
his share of the multibillion-dollar supplement
business, and he doesn't care if anybody gets
hurt by his advice. He is completely amoral.
Biochem Pharmacol. 2003 Jan 1;65(1):75-82.
Reversal of P-glycoprotein-mediated multidrug
resistance by ginsenoside Rg(3).
Kim SW, Kwon HY, Chi DW, Shim JH, Park JD,
Lee YH, Pyo S, Rhee DK.
College of Pharmacy, SungKyunKwan University,
Su-Won 440-746, South Korea.
Multidrug resistance has been a major problem in
cancer chemotherapy. In this study, in vitro and
in vivo modulations of MDR by ginsenoside Rg(3),
a red ginseng saponin, were investigated. In flow
cytometric analysis using rhodamine 123 as an
artificial substrate, Rg(3) promoted accumulation
of rhodamine 123 in drug-resistant KBV20C cells
in a dose-dependent manner, but it had no effect
on parental KB cells. Additionally Rg(3) inhibited
[3H]vinblastine efflux and reversed MDR to
doxorubicin, COL, VCR, and VP-16 in KBV20C cells.
Reverse transcriptase-polymerase chain reaction
and immuno-blot analysis after exposure of KBV20C
cells to Rg(3) showed that inhibition of drug
efflux by Rg(3) was due to neither repression of
MDR1 gene expression nor Pgp level. Photo-affinity
labeling study with [3H]azidopine, however,
revealed that Rg(3) competed with [3H]azidopine
for binding to the Pgp demonstrating that Rg(3)
competed with anticancer drug for binding to Pgp
thereby blocking drug efflux. Furthermore, Rg(3)
increased life span in mice implanted with
DOX-resistant murine leukemia P388 cells in vivo
and inhibited body weight increase significantly.
.
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