Re: Air Pollution and Spamming Don't Mix
- From: Mark Thorson <nospam@xxxxxxxxx>
- Date: Mon, 30 Jul 2007 12:10:54 -0700
"D." wrote:
For anyone experiencing high cholesterol, getting out of traffic
and into the country would be a very, very healthy idea. Although
it wasn't mentioned in the article, their research seems to suggest
that anti-oxidants in supplement form would be beneficial.
You're putting words in their mouth to spin this
article as favorable to the supplement companies
that you'd like to have sponsoring your commercial
blogspot web site. In a recent review of
the effects of antioxidant supplements, three
(beta-carotene, vitamin A, and vitamin E)
raised all-cause mortality (death), while two
supplements (vitamin C and selenium) had no
significant effect.
But of course, you don't want the general public
to know that. You want to get your share of the
profits of the supplement industry, even if it
means shortening the lives of the people who
read your poorly researched, deceptive articles.
JAMA. 2007 Feb 28;297(8):842-57.
Mortality in randomized trials of antioxidant
supplements for primary and secondary prevention:
systematic review and meta-analysis.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG,
Gluud C.
The Cochrane Hepato-Biliary Group, Copenhagen
Trial Unit, Center for Clinical Intervention
Research, Copenhagen University Hospital,
Rigshospitalet, Copenhagen, Denmark.
CONTEXT: Antioxidant supplements are used for
prevention of several diseases.
OBJECTIVE: To assess the effect of antioxidant
supplements on mortality in randomized primary
and secondary prevention trials.
DATA SOURCES AND TRIAL SELECTION: We searched
electronic databases and bibliographies published
by October 2005. All randomized trials involving
adults comparing beta carotene, vitamin A, vitamin C
(ascorbic acid), vitamin E, and selenium either
singly or combined vs placebo or vs no intervention
were included in our analysis. Randomization,
blinding, and follow-up were considered markers
of bias in the included trials. The effect of
antioxidant supplements on all-cause mortality
was analyzed with random-effects meta-analyses
and reported as relative risk (RR) with 95%
confidence intervals (CIs). Meta-regression
was used to assess the effect of covariates
across the trials.
DATA EXTRACTION: We included 68 randomized trials
with 232 606 participants (385 publications).
DATA SYNTHESIS: When all low- and high-bias risk
trials of antioxidant supplements were pooled
together there was no significant effect on
mortality (RR, 1.02; 95% CI, 0.98-1.06).
Multivariate meta-regression analyses showed
that low-bias risk trials (RR, 1.16; 95% CI,
1.05-1.29) and selenium (RR, 0.998; 95% CI,
0.997-0.9995) were significantly associated with
mortality. In 47 low-bias trials with 180 938
participants, the antioxidant supplements
significantly increased mortality (RR, 1.05; 95%
CI, 1.02-1.08). In low-bias risk trials, after
exclusion of selenium trials, beta carotene
(RR, 1.07; 95% CI, 1.02-1.11), vitamin A
(RR, 1.16; 95% CI, 1.10-1.24), and vitamin E
(RR, 1.04; 95% CI, 1.01-1.07), singly or
combined, significantly increased mortality.
Vitamin C and selenium had no significant
effect on mortality.
CONCLUSIONS: Treatment with beta carotene,
vitamin A, and vitamin E may increase mortality.
The potential roles of vitamin C and selenium
on mortality need further study.
.
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