Re: Any natural sleep inducers, I need a sleep aid?


tttvvv wrote:
I have trouble falling asleep, but don't want to use drugs. Any
natural herbs or something to do that? I have already tired valarien
root and greens plus sleep and chamomile tea, but none have helped. tx

1: Nutr Neurosci. 2005 Apr;8(2):121-7. Links
Protein source tryptophan versus pharmaceutical grade tryptophan as an
efficacious treatment for chronic insomnia.Hudson C, Hudson SP, Hecht
T, MacKenzie J.
Biosential Inc., 1543 Bayview Avenue, Suite 346, Toronto, Ontario M4G
3B5, Canada. craighudson@xxxxxxxxxxxxxx

BACKGROUND: Intact protein rich in tryptophan was not seen as an
alternative to pharmaceutical grade tryptophan since protein also
contains large neutral amino acids (LNAAs) that compete for transport
sites across the blood-brain barrier (BBB). Deoiled gourd seed (an
extremely rich source of tryptophan-22 mg tryptophan/1 g protein) was
combined with glucose, a carbohydrate that reduces serum levels of
competing LNAAs which was then compared to pharmaceutical grade
tryptophan with carbohydrate as well as carbohydrate alone. METHOD:
Objective and subjective measures of sleep were employed to measure
changes in sleep as part of a double blind placebo controlled study
where subjects were randomly assigned to one of three conditions: (1)
Protein source tryptophan (deoiled gourd seed) in combination with
carbohydrate; (2) pharmaceutical grade tryptophan in combination with
carbohydrate; (3) carbohydrate alone. SUBJECTS: Out of 57 subjects 49
of those who began the study completed the three week protocol.
RESULTS: Protein source tryptophan with carbohydrate and pharmaceutical
grade tryptophan, but not carbohydrate alone, resulted in significant
improvement on subjective and objective measures of insomnia. Protein
source tryptophan with carbohydrate alone proved effective in
significantly reducing time awake during the night. CONCLUSION: Protein
source tryptophan is comparable to pharmaceutical grade tryptophan for
the treatment of insomnia.

PMID: 16053244 [PubMed - indexed for MEDLINE]


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Tom


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