Re: An Education For Vaccine-Man
- From: "JanD" <JanD@xxxxxxxxxxxxx>
- Date: Sat, 26 Nov 2005 01:27:56 GMT
"Mark Probert" <markprobert@xxxxxxxxxxxxxxxx> wrote
> JanD wrote:
>> Vaccine-Man wrote:
>> Have you seen this paper?
>> The 'memory lymphocyte immunostimulation assay' (MELISA) is useless for
>> the detection of metal allergy
>> Koene RA. Ned Tijdschr Geneeskd. 2005 Sep 17;149(38):2090-2.
>> For the past several years, there has been an advertising campaign,
>> especially focused on dentists, to promote the so-called 'memory
>> lymphocyte immunostimulation assay' (MELISA) for the detection of metal
>> allergy. A study of the sparse scientific literature reveals that, as a
>> consequence of the high number of false-positive results, this test is
>> of no use for the diagnosis of metal allergy. Moreover, the claims of
>> the developers of the test that metal allergy plays a role in several
>> immune-mediated diseases, metabolic diseases and neurological or mental
>> disorders are not based on sound scientific evidence.
>> He also questioned if mercury was allergenic.
>> Mostly to harras IIena.
>> This is his wake up call.
>> Int J Mol Med. 2005 Dec;16(6):971-7.
>> Thimerosal induces neuronal cell apoptosis by causing cytochrome c and
>> apoptosis-inducing factor release from mitochondria.
>> Yel L, Brown LE, Su K, Gollapudi S, Gupta S.
>> Immunology/Medicine, C240 Med Sci I, University of California, Irvine, CA
>> 92697, USA. lyel@xxxxxxxx
>> There is a worldwide increasing concern over the neurological risks of
>> thimerosal (ethylmercury thiosalicylate) which is an organic mercury
>> compound that is commonly used as an antimicrobial preservative. In this
>> study, we show that thimerosal, at nanomolar concentrations, induces
>> neuronal cell death through the mitochondrial pathway. Thimerosal, in a
>> concentration- and time-dependent manner, decreased cell viability as
>> assessed by calcein-ethidium staining and caused apoptosis detected by
>> Hoechst 33258 dye. Thimerosal-induced apoptosis was associated with
>> depolarization of mitochondrial membrane, generation of reactive oxygen
>> species, and release of cytochrome c and apoptosis-inducing factor (AIF)
>> from mitochondria to cytosol. Although thimerosal did not affect cellular
>> expression of Bax at the protein level, we observed translocation of Bax
>> from cytosol to mitochondria. Finally, caspase-9 and caspase-3 were
>> activated in the absence of caspase-8 activation. Our data suggest that
>> thimerosal causes apoptosis in neuroblastoma cells by changing the
>> mitochondrial microenvironment.
>> PMID: 16273274 [PubMed - in process]
>> Neuro Endocrinol Lett. 2005 Oct 30;26(5) [Epub ahead of print]
>> Mercury and autism: Accelerating Evidence?
>> Mutter J, Naumann J, Schneider R, Walach H, Haley B.
>> Institute for Environmental Medicine and Hospital Epidemiology,
>> University Hospital Freiburg, Germany.
>> The causes of autism and neurodevelopmental disorders are unknown.
>> Genetic and environmental risk factors seem to be involved. Because of an
>> observed increase in autism in the last decades, which parallels
>> cumulative mercury exposure, it was proposed that autism may be in part
>> caused by mercury. We review the evidence for this proposal. Several
>> epidemiological studies failed to find a correlation between mercury
>> exposure through thimerosal, a preservative used in vaccines, and the
>> risk of autism. Recently, it was found that autistic children had a
>> higher mercury exposure during pregnancy due to maternal dental amalgam
>> and thimerosal-containing immunoglobulin shots. It was hypothesized that
>> children with autism have a decreased detoxification capacity due to
>> genetic polymorphism. In vitro, mercury and thimerosal in levels found
>> several days after vaccination inhibit methionine synthetase (MS) by 50%.
>> Normal function of MS is crucial in biochemical steps necessary for brain
>> development, attention and production of glutathione, an important
>> antioxidative and detoxifying agent. Repetitive doses of thimerosal leads
>> to neurobehavioral deteriorations in autoimmune susceptible mice,
>> increased oxidative stress and decreased intracellular levels of
>> glutathione in vitro. Subsequently, autistic children have significantly
>> decreased level of reduced glutathione. Promising treatments of autism
>> involve detoxification of mercury, and supplementation of deficient
>> PMID: 16264412 [PubMed - as supplied by publisher]
>> Studies have demonstrated that the removal of dental mercury amalgam
>> can result in definitive and significant improvements in overall health
>> status.The Foundation for Toxic-Free Dentistry compiled data on 1,569
>> from six different sources. Of particular interest in the FTFD analysis
>> isthe fact that 14% of patients experienced some form of allergic
>> and that 89% reported that their condition had improved or was entirely
>> eliminated after removal of their silver/mercury dental amalgam
>> fillings.Systemic mercury toxicity appears to have a direct causal
>> to the development of allergic sensitivity to foods, chemicals and other
>> environmental factors.
>> Extrapolating the FTFD data to the approximately 140 million individuals
>> mercury dental amalgams in the U.S, there would be about 19.6million
>> (14%) with mercury amalgam-related allergies, and, 89% or about17.4
>> people would experience the amelioration or disappearance of their
>> allergies by
>> simply having their silver/ mercury dental amalgam fillings replaced with
>> non-mercury, hypoallergenic composite dental fillings.
>> Neuro Endocrinol Lett. 2004 Jun;25(3):211-8.
>> The beneficial effect of amalgam replacement on health in patients with
>> Prochazkova J, Sterzl I, Kucerova H, Bartova J, Stejskal VD.
>> The Institute of Dental Research 1st Medical Faculty Charles University
>> and General University Hospital, Prague, Czech Republic.
>> BACKGROUND: Patients with certain autoimmune and allergic diseases, such
>> as systemic lupus, multiple sclerosis, autoimmune thyroiditis or atopic
>> eczema, often show increased lymphocyte stimulation by low doses of
>> inorganic mercury in vitro. The patients often report clinical metal
>> hypersensitivity, especially to nickel. OBJECTIVE AND METHODS: In this
>> study we examined the health impact of amalgam replacement in
>> mercury-allergic patients with autoimmunity. The suitability of MELISA,
>> an optimized lymphocyte stimulation test, for the selection of
>> susceptible patients and monitoring of sensitization was also examined.
>> Amalgam fillings were replaced with composites and ceramic materials.
>> Follow-up health status and lymphocyte reactivity were assessed and
>> evaluated half a year or later following amalgam removal. RESULTS:
>> Results of lymphocyte reactivity measured with MELISA indicate that in
>> vitro reactivity after the replacement of dental amalgam decreased
>> significantly to inorganic mercury, silver, organic mercury and lead. Out
>> of 35 patients, 25 patients (71%) showed improvement of health. The
>> remaining patients exhibited either unchanged health (6 patients, 17%) or
>> worsening of symptoms (4 patients, 11%). The highest rate of improvement
>> was observed in patients with multiple sclerosis, the lowest rate was
>> noted in patients with eczema. The initial mercury-specific lymphocyte
>> reactivity was significantly higher in the responder group, than in the
>> non-responders, whose health was not improved by amalgam removal. All
>> patients with health improvement after amalgam replacement showed reduced
>> proliferation to inorganic mercury in follow-up MELISA. In vitro
>> responses to phenylmercury and nickel did not differ between the groups.
>> CONCLUSIONS: Mercury-containing amalgam may be an important risk factor
>> for patients with autoimmune diseases. MELISA is a valuable tool for
>> selection of patients for amalgam replacement and also for monitoring of
>> metal allergies.
>> PMID: 15349088 [PubMed - indexed for MEDLINE]
- Re: An Education For Vaccine-Man
- From: Mark Probert
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