Re: An Education For Vaccine-Man
- From: Mark Probert <markprobert@xxxxxxxxxxxxxxxx>
- Date: Fri, 25 Nov 2005 11:59:13 -0500
Vaccine-Man wrote: Have you seen this paper?
The 'memory lymphocyte immunostimulation assay' (MELISA) is useless for the detection of metal allergy
Koene RA. Ned Tijdschr Geneeskd. 2005 Sep 17;149(38):2090-2.
For the past several years, there has been an advertising campaign, especially focused on dentists, to promote the so-called 'memory lymphocyte immunostimulation assay' (MELISA) for the detection of metal allergy. A study of the sparse scientific literature reveals that, as a consequence of the high number of false-positive results, this test is of no use for the diagnosis of metal allergy. Moreover, the claims of the developers of the test that metal allergy plays a role in several immune-mediated diseases, metabolic diseases and neurological or mental disorders are not based on sound scientific evidence.
He also questioned if mercury was allergenic.
Mostly to harras IIena.
Not really. Your handler brought up a comment I made about mercury allergy, where I was corrected by someone who provided facts. I accepted the correction, something that you should learn to do, and your handler persisted in her attacks on me.
This is his wake up call.
Jan, do you know what this means in relation to the previous discussion? OF course you do not.
Int J Mol Med. 2005 Dec;16(6):971-7.
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria.
Yel L, Brown LE, Su K, Gollapudi S, Gupta S.
Immunology/Medicine, C240 Med Sci I, University of California, Irvine, CA 92697, USA. lyel@xxxxxxxx
There is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative. In this study, we show that thimerosal, at nanomolar concentrations, induces neuronal cell death through the mitochondrial pathway. Thimerosal, in a concentration- and time-dependent manner, decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye. Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane, generation of reactive oxygen species, and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol. Although thimerosal did not affect cellular expression of Bax at the protein level, we observed translocation of Bax from cytosol to mitochondria. Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment.
PMID: 16273274 [PubMed - in process]
Neuro Endocrinol Lett. 2005 Oct 30;26(5) [Epub ahead of print]
Mercury and autism: Accelerating Evidence?
Mutter J, Naumann J, Schneider R, Walach H, Haley B.
Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany. joachim.mutter@xxxxxxxxxxxxxxxxxxxxxx
The causes of autism and neurodevelopmental disorders are unknown. Genetic and environmental risk factors seem to be involved. Because of an observed increase in autism in the last decades, which parallels cumulative mercury exposure, it was proposed that autism may be in part caused by mercury. We review the evidence for this proposal. Several epidemiological studies failed to find a correlation between mercury exposure through thimerosal, a preservative used in vaccines, and the risk of autism. Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites.
PMID: 16264412 [PubMed - as supplied by publisher]
Studies have demonstrated that the removal of dental mercury amalgam fillings
can result in definitive and significant improvements in overall health
status.The Foundation for Toxic-Free Dentistry compiled data on 1,569 patients
from six different sources. Of particular interest in the FTFD analysis report
isthe fact that 14% of patients experienced some form of allergic symptomology
and that 89% reported that their condition had improved or was entirely
eliminated after removal of their silver/mercury dental amalgam
fillings.Systemic mercury toxicity appears to have a direct causal relationship
to the development of allergic sensitivity to foods, chemicals and other
Extrapolating the FTFD data to the approximately 140 million individuals with
mercury dental amalgams in the U.S, there would be about 19.6million people
(14%) with mercury amalgam-related allergies, and, 89% or about17.4 million
people would experience the amelioration or disappearance of their allergies by
simply having their silver/ mercury dental amalgam fillings replaced with
non-mercury, hypoallergenic composite dental fillings.
Neuro Endocrinol Lett. 2004 Jun;25(3):211-8.
The beneficial effect of amalgam replacement on health in patients with autoimmunity.
Prochazkova J, Sterzl I, Kucerova H, Bartova J, Stejskal VD.
The Institute of Dental Research 1st Medical Faculty Charles University and General University Hospital, Prague, Czech Republic. prochazkova@xxxxxx
BACKGROUND: Patients with certain autoimmune and allergic diseases, such as systemic lupus, multiple sclerosis, autoimmune thyroiditis or atopic eczema, often show increased lymphocyte stimulation by low doses of inorganic mercury in vitro. The patients often report clinical metal hypersensitivity, especially to nickel. OBJECTIVE AND METHODS: In this study we examined the health impact of amalgam replacement in mercury-allergic patients with autoimmunity. The suitability of MELISA, an optimized lymphocyte stimulation test, for the selection of susceptible patients and monitoring of sensitization was also examined. Amalgam fillings were replaced with composites and ceramic materials. Follow-up health status and lymphocyte reactivity were assessed and evaluated half a year or later following amalgam removal. RESULTS: Results of lymphocyte reactivity measured with MELISA indicate that in vitro reactivity after the replacement of dental amalgam decreased significantly to inorganic mercury, silver, organic mercury and lead. Out of 35 patients, 25 patients (71%) showed improvement of health. The remaining patients exhibited either unchanged health (6 patients, 17%) or worsening of symptoms (4 patients, 11%). The highest rate of improvement was observed in patients with multiple sclerosis, the lowest rate was noted in patients with eczema. The initial mercury-specific lymphocyte reactivity was significantly higher in the responder group, than in the non-responders, whose health was not improved by amalgam removal. All patients with health improvement after amalgam replacement showed reduced proliferation to inorganic mercury in follow-up MELISA. In vitro responses to phenylmercury and nickel did not differ between the groups. CONCLUSIONS: Mercury-containing amalgam may be an important risk factor for patients with autoimmune diseases. MELISA is a valuable tool for selection of patients for amalgam replacement and also for monitoring of metal allergies.
PMID: 15349088 [PubMed - indexed for MEDLINE]
- Re: An Education For Vaccine-Man
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