Re: Stanford LDN Study


<D_Frumious_B@xxxxxxxxxxx> wrote in message
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BigArtie <XXX@.com> wrote:

<D_Frumious_B@xxxxxxxxxxx> wrote in message
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Somebody posted a link to an LDN study at Stanford. I've been unable
to find it again amid the morass that this NG has become, but I decided
that it merited a reply:

I looked at the study you cited. It was a study of the effects of
LDN on PAIN in FIBROMYALGIA patients. MS was mentioned only in
passing.
The study was single-blind, not double blind. There were only ten
participants, all women. The study covered a very short time period:
two weeks baseline, two weeks during which all participants received
placebos, eight weeks during which all participants received LDN, and a
two week "washout" period.
I was unimpressed with the methodology, and with the results. The
drug worked on only 60% of the (admittedly minuscule) test group. Long
term effects were not studied at all. And the pain reduction wasn't
particularly impressive. Also, while the pain ratings were on a scale
of 0 to 100, the graphic shown only extends from 0 to 90, distorting
the
results to the uncritical eye.
Most relevant to the topic (anyone remember an old concept called
"topicality?") of this NG is this statement by the researchers
(emphasis
added):

"When given at a smaller dose... the drug MAY help to reduce PAIN
associated with inflammatory and AUTOIMMUNE conditions, such as
multiple
sclerosis and Crohn's disease."

Not lesions, not long-term effects, not demyelinization - it "may"
help reduce "pain." And MS is an *autoimmune* condition.
I know one MS patient who is in chronic, severe pain from her
disease. For her, maybe this would be helpful. But I also know
numerous PWMS whose problem is not pain, but loss of sensation, motor
control, and vision. I don't see how a pain med would be beneficial
for
them.

This the best you've got, guys?


Bill

In MS LDN can relieve pain but it's not LDN's main purpose for those with
MS. In MS LDN's main purpose is to halt disease progression over several
months use, if one with MS gets symptom improvement using LDN then that's
an
added bonus. I have heard that LDN has helped Fibromyalgia pain for many
but
not all, some have discovered they have been misdiagnosed and actually
have
Lyme disease which mimics many autoimmune diseases. For Fibro, trial and
error but well worth a trial in my opinion, each person is different.

So where's the science that says LDN halts the progression of MS?
Anecdotal evidence is not science. Where is the controlled,
statistically significant, double-blind, rigorous, replicable science?
If you ever show me such a thing I promise I will print it out and mail
a hard copy to my daughter's neuro, because she studies MS continually,
and she says there is NO such science.
BTW, any competent diagnostician can distinguish Lyme's from an
autoimmune diseases.


Bill


All of the research money for MS is being spent on medications other than
LDN.
No money = no research and scientific proof.

Why the Silence About LDN?
http://tinyurl.com/the-silence-about-ldn


And you are wrong about Lyme disease being easily diagnosed:

LYME DISEASE AWARENESS, A FAMILY'S PERSONAL STORY OF MISDIAGNOSIS, ALMOST
TRAGEDY WITH SON'S LACK OF PROPER DIAGNOSIS.
http://www.freewebs.com/lymeandautism/

LYME DISEASE MISDIAGNOSED AS: ALS, Alzheimer's, Parkinson's, Sjogren's
Syndrome, etc, etc...
http://www.endowmentmed.org/pdf/updatelyme.pdf

My Story - BetterHealthGuy.com
http://www.betterhealthguy.com/index.php....id=22&Itemid=72

NUTRACEUTICAL BREAKTHROUGHS IN LYME DISEASE
http://www.springboard4health.com/notebook/health_lyme_disease.html

Under Our Skin
http://www.underourskin.com/index.html



.

Relevant Pages

  • Re: Stanford LDN Study
    ... LDN on PAIN in FIBROMYALGIA patients. ... sclerosis and Crohn's disease." ... So where's the science that says LDN halts the progression of MS? ...
    (alt.support.mult-sclerosis)
  • Re: Stanford LDN Study
    ... LDN on PAIN in FIBROMYALGIA patients. ... sclerosis and Crohn's disease." ... The Mail Tribune of Southern Oregon: Naltrexone Halts a Patient's Advanced ...
    (alt.support.mult-sclerosis)
  • Re: HELP - reactions to first week LDN use
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    ... Even with the LDN bullshit, the increased pain could very well be from doctors who don't get the fact that pain drugs and LDN have no connection. ... And its the same with the RSD ketamine trip too. ...
    (alt.support.chronic-pain)
  • Re: Death from Inappropriate Therapy for Lyme Disease
    ... >Death from Inappropriate Therapy for Lyme Disease ... >a history of bilateral knee pain since childhood. ... >specializes in chronic Lyme disease and was diagnosed with chronic Lyme ...
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