Score one for B-6, at least until the referees rule on the replay
- From: randyf <randy@xxxxxxx>
- Date: Fri, 29 Jun 2012 07:03:39 -0700 (PDT)
B6 Deficit Tied to CV Disease Risk
By Crystal Phend, Senior Staff Writer, MedPage Today
Published: June 28, 2012
Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of
Medicine at the University of Pennsylvania and Dorothy Caputo, MA,
BSN, RN, Nurse Planner
Action Points
This study found lower levels of pyridoxal-5-phosphate, a marker of
vitamin B-6, associated with an increased overall inflammation score
based upon 13 individual inflammatory markers in a community-based
cohort.
Point out that the same associations with overall inflammation were
not seen with other B vitamins, namely plasma folate or vitamin B12.
Low levels of vitamin B6 may play a role in the chronic inflammation
that contributes to cardiovascular disease and other common
conditions, researchers found.
The top scorers across a panel of inflammatory markers had
significantly lower levels of pyridoxal-5-phosphate (PLP) as a plasma
marker of vitamin B6 status than the least inflamed individuals in an
analysis of the Framingham Offspring cohort study (61 nmol/L versus 80
nmol/L, P<0.0001 for trend).
The prevalence of inadequate levels of vitamin B6 marked by PLP under
20 nmol/L roughly doubled across the inflammation tertiles, Lydia
Sakakeeny, PhD, of the U.S. Department of Agriculture Human Nutrition
Research Center at Tufts University in Boston, and colleagues
reported.
"Low vitamin B-6 status, based on plasma concentrations of PLP, has
been identified in inflammatory diseases, including cardiovascular
disease, rheumatoid arthritis, inflammatory bowel disease, and
diabetes," the group wrote in the July issue of the Journal of
Nutrition.
"This study, in combination with past findings, further supports our
hypothesis that inflammation is associated with a functional
deficiency of vitamin B6," they added.
The analysis included 2,229 men and women in the 1998-2001 round of
examinations in the community-based Framingham Offspring study.
Greater inflammation correlated with lower plasma PLP levels for the
primary measure summing scores on standardized values of 13 individual
inflammatory markers, including interleukin-6, tumor necrosis factor
alpha, and intercellular adhesion molecule-1.
The same was true across various functional groups of inflammation
markers.
For both the acute phase reactant markers (C-reactive protein and
fibrinogen) and the cytokines (IL-6, TNF factors, and
osteoprotegerin), plasma PLP averages went from 76 nmol/L in the
lowest inflammatory tertile to 61 nmol/L in the top tertile. Both
trends were significant at P<0.001.
Likewise for the oxidative stress grouping, plasma PLP averaged 73
nmol/L in the lowest scoring tertile to 63 nmol/L in the highest
tertile (P<0.0001 for trend).
The selectins -- P-selectin and CD40L -- tended to follow the same
trend but missed statistical significance (P=0.08 for trend).
These multivariate-adjusted associations persisted with additional
adjustment for C-reactive protein.
The only marker without a significant correlation to vitamin B6 was
serum monocyte chemotactic protein-1 (MCP-1).
High vitamin B6 intake was linked to higher plasma PLP levels, as
expected. Yet the most inflamed individuals had significantly lower
plasma PLP levels than the least inflamed participants, even after
controlling for how much of the water-soluble vitamin people got in
their diet.
A sensitivity analysis excluding individuals with preexisting
cardiovascular disease or diabetes turned up essentially the same
results.
Notably, the same associations with overall inflammation weren't seen
with other B vitamins -- plasma folate or vitamin B12, suggesting the
link was specific, the researchers noted.
Research into the mechanism for the vitamin B6 link is warranted, they
suggested, but "an attractive hypothesis is that the low plasma PLP is
a reflection of mobilization of this coenzyme into inflammatory
sites."
The observational findings couldn't determine causality.
Another limitation was that the population studied had higher average
vitamin B6 intake compared with the national population, at 3.1 mg per
day from food and supplements versus 1.6 mg in the NHANES study over a
similar period.
The largely white population of European ancestry might also have
limited generalizability.
.
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