Re: Caloric Restriction Linked to Reduced Inflammation Markers

On 5/5/2012 8:17 AM, GysdeJongh wrote:
Another randomized control trial which found that eating less is good
for your health. We have literally hundreds of those now.

Because this is an other *Randomized* control trial the usual suspects
cannot sing their "causation is no corellation" song. Which is not only
nice for saving their asses but also implies (for them) that they posses
a superior knowledge and an academic degree in statistics from a
respectable university.

There will be also the usual contributions like : "I never saw an obese
postmenopausal woman, where are they ?" And "My MIL was a very big woman
who lived a very happy life. She died at the age of 115 years without
ever been ill"

<http://www.diabetesincontrol.com>

Caloric Restriction Linked to Reduced Inflammation Markers

Implementation of a caloric restriction weight-loss diet, with or
without exercise, is associated with measurable reductions in markers of
inflammation for obese or overweight postmenopausal women, according to
a study.

Ikuyo Imayama examined the effects of a caloric restriction weight-loss
diet and exercise on inflammatory biomarkers in 438 overweight and obese
postmenopausal women. Participants were randomly allocated to one year
of a caloric restriction diet (goal of 10 percent weight loss; 118
women); aerobic exercise (225 minutes per week of moderate-to-vigorous
activity; 117 women); combined diet + exercise (116 women); or control
(87 women). High-sensitivity C-reactive protein (hs-CRP), serum amyloid
A (SAA), interleukin-6 (IL-6), leukocyte, and neutrophil levels were
measured at baseline and one year by blinded investigators.

The researchers found that, compared to the control group, hs-CRP, IL-6,
and neutrophil counts decreased significantly in the diet and diet +
exercise groups. Inflammatory biomarkers hs-CRP, SAA, and IL-6 were
reduced for participants in the diet and diet + exercise groups that
lost 5 percent or more of their weight, compared with controls.

"Our findings indicate that a caloric restriction weight loss diet with
or without exercise reduces biomarkers of inflammation in postmenopausal
women, with potential clinical significance for cancer risk reduction,"
the authors write.

Cancer Res. 2012 May 1;72(9):2314-2326.
Effects of a Caloric Restriction Weight Loss Diet and Exercise on
Inflammatory Biomarkers in Overweight/Obese Postmenopausal Women: A
Randomized Controlled Trial.
PMID: 22549948

So,
do your thing and have fun
Gys

well, correlation does NOT prove causality, no matter HOW randomized

It is a shame that Americans get such a lousy education in Math.

Randomized studies definitely increase the potential validity of the study, they NEVER prove causality. For a simple example, we know that there is a correlation between weight and T2 diabetes. There has, so far, been no way to prove which causes which. The majority believe it is weight causes diabetes. A STRONG minority believe diabetes causes weight gain, but neither opinion has PROOF, and a randomized study, no mater how randomized, will show a correlation only.

One of the reason the "supplement" scammers do so well, is that people like you didn't flunk Statistics 101, they never were even exposed to it.
.

Relevant Pages

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