Re: Milk and soy protein shave 2 mm Hg off systolic BP

Fermented milk product?

1. Clin Exp Hypertens. 2011 Jun 7. [Epub ahead of print]

Ile-Pro-Pro and Val-Pro-Pro Tripeptide-Containing
Milk Product has Acute Blood Pressure Lowering
Effects in Mildly Hypertensive Subjects.

Turpeinen AM, Ehlers PI, Kivimäki AS, Järvenpää S,
Filler I, Wiegert E, Jähnchen E, Vapaatalo H,
Korpela R, Wagner F.

Valio Ltd., R&D , Helsinki , Finland.

Casein-derived tripeptides isoleucine-proline-proline
(Ile-Pro-Pro) and valine-proline-proline (Val-Pro-Pro)
lower blood pressure (BP) in long-term clinical studies.
Their acute effects on BP and vascular function,
important for daily dosing scheme, were studied
in a placebo-controlled double-blind crossover
study using a single oral dose of a fermented milk
product containing Ile-Pro-Pro and Val-Pro-Pro as well
as plant sterols. Twenty-five subjects with untreated
mild hypertension received in random order 250 g
of study product (25 mg peptides and 2 g plant sterols)
or placebo. Ambulatory BP was monitored for 8 h post-dose
and arterial stiffness measured by pulse wave analysis
at 2, 4, and 8 h. Blood and urine samples were analyzed
for markers of the renin-angiotensin system (RAS)
and endothelial function. Baseline adjusted treatment
effect for systolic blood pressure (SBP), diastolic blood
pressure (DBP), and mean arterial BP was
-2.1 mmHg (95% CI: -4.1 to -0.1, p = 0.045),
-1.6 mmHg (95% CI: -3.1 to -0.1, p = 0.03), and
-1,9 mmHg (95% CI: -3-3 to -0.4, p = 0.0093), respectively,
in favor of the active treatment for 8 h post- dose.
No significant differences between the treatments were
seen in brachial or aortic augmentation index, pulse wave
velocity, or markers of RAS. Urinary excretion of cGMP,
the second messenger of endothelial nitric oxide,
was higher in the active group vs. placebo (p = 0.01).
The results indicate that a single dose of
a fermented milk product containing
Ile-Pro-Pro and Val-Pro-Pro and plant sterols
acutely lowers brachial SBP and DBP
in mildly hypertensive subjects.


PMID: 21649532 [PubMed - as supplied by publisher]
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