Re: Dietary ketosis enhances memory in mild cognitive impairment.
- From: "randy@xxxxxxx" <randy@xxxxxxx>
- Date: Sat, 26 Mar 2011 19:30:44 -0700 (PDT)
On Mar 26, 9:21 pm, "W. Baker" <wba...@xxxxxxxxx> wrote:
ra...@xxxxxxx <ra...@xxxxxxx> wrote:
: Then again very very low carb diets might help some brain functions.
: But the authors didn't control of calorie intake. Nevertheless worth
: mentioning.
: Regards
: Randy
: //************************************************
: Dietary ketosis enhances memory in mild cognitive impairment.
: Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ.
: Department of Psychiatry and Behavioral Neuroscience, University of
: Cincinnati, Cincinnati, OH, USA.
: Abstract
: We randomly assigned 23 older adults with mild cognitive impairment to
: either a high carbohydrate or very low carbohydrate diet. Following
: the 6-week intervention period, we observed improved verbal memory
: performance for the low carbohydrate subjects (p = 0.01) as well as
: reductions in weight (p < 0.0001), waist circumference (p < 0.0001),
: fasting glucose (p = 0.009), and fasting insulin (p = 0.005). Level of
: depressive symptoms was not affected. Change in calorie intake,
: insulin level, and weight were not correlated with memory performance
: for the entire sample, although a trend toward a moderate relationship
: between insulin and memory was observed within the low carbohydrate
: group. Ketone levels were positively correlated with memory
: performance (p = 0.04). These findings indicate that very low
: carbohydrate consumption, even in the short term, can improve memory
: function in older adults with increased risk for Alzheimer's disease.
: While this effect may be attributable in part to correction of
: hyperinsulinemia, other mechanisms associated with ketosis such as
: reduced inflammation and enhanced energy metabolism also may have
: contributed to improved neurocognitive function. Further investigation
: of this intervention is warranted to evaluate its preventive potential
: and mechanisms of action in the context of early neurodegeneration.
: Copyright ? 2010 Elsevier Inc. All rights reserved.
: PMID: 21130529 [PubMed - as supplied by publisher]
Something very ineresting in this discussion of ketosis. I was not aware
that ketosis reducs inflammation. The comments in here lately, which keep
talking about sat fats and inflammation would have led me to believe that
ketosis, from low carb diets would not have that anti-inflammatory effect,
but there it is!.
Wendy
Most studies show ketotic diets increase inflammation.
Note that the authors did not mearsure inflammation, speculate that
inflammation is reduced and that might be the source of the improved
neuro function.
Here's one study:
Full paper here: http://www.ajcn.org/content/83/5/1055.full
//******************************
Ketogenic low-carbohydrate diets have no metabolic advantage over
nonketogenic low-carbohydrate diets.
Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears B.
Department of Nutrition, Arizona State University, Mesa, AZ 85212,
USA. carol.johnston@xxxxxxx
Comment in:
Am J Clin Nutr. 2007 Jan;85(1):238-9; author reply 239-40.
Abstract
BACKGROUND: Low-carbohydrate diets may promote greater weight loss
than does the conventional low-fat, high-carbohydrate diet.
OBJECTIVE: We compared weight loss and biomarker change in adults
adhering to a ketogenic low-carbohydrate (KLC) diet or a nonketogenic
low-carbohydrate (NLC) diet.
DESIGN: Twenty adults [body mass index (in kg/m(2)): 34.4 +/- 1.0]
were randomly assigned to the KLC (60% of energy as fat, beginning
with approximately 5% of energy as carbohydrate) or NLC (30% of energy
as fat; approximately 40% of energy as carbohydrate) diet. During the
6-wk trial, participants were sedentary, and 24-h intakes were
strictly controlled.
RESULTS: Mean (+/-SE) weight losses (6.3 +/- 0.6 and 7.2 +/- 0.8 kg in
KLC and NLC dieters, respectively; P = 0.324) and fat losses (3.4 and
5.5 kg in KLC and NLC dieters, respectively; P = 0.111) did not differ
significantly by group after 6 wk. Blood beta-hydroxybutyrate in the
KLC dieters was 3.6 times that in the NLC dieters at week 2 (P =
0.018), and LDL cholesterol was directly correlated with blood beta-
hydroxybutyrate (r = 0.297, P = 0.025). Overall, insulin sensitivity
and resting energy expenditure increased and serum gamma-
glutamyltransferase concentrations decreased in both diet groups
during the 6-wk trial (P < 0.05). However, inflammatory risk
(arachidonic acid:eicosapentaenoic acid ratios in plasma
phospholipids) and perceptions of vigor were more adversely affected
by the KLC than by the NLC diet.
CONCLUSIONS: KLC and NLC diets were equally effective in reducing body
weight and insulin resistance, but the KLC diet was associated with
several adverse metabolic and emotional effects. The use of ketogenic
diets for weight loss is not warranted.
.
- References:
- Dietary ketosis enhances memory in mild cognitive impairment.
- From: randy@xxxxxxx
- Re: Dietary ketosis enhances memory in mild cognitive impairment.
- From: W. Baker
- Dietary ketosis enhances memory in mild cognitive impairment.
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