Glucose-responsive insulin?
- From: "Pro-Humanist FREELOVER" <prohuman@xxxxxxxxxxxx>
- Date: Fri, 3 Dec 2010 11:15:08 -0600
- - -
December 2, 2010
Glucose-responsive insulin advances
toward clinical development
http://www.eurekalert.org/pub_releases/2010-12/jdrf-mas_1120210.php
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Excerpts [with inserts, not part of original article,
included in brackets]:
Today pharmaceutical company, Merck & Co., Inc.
announced it will acquire SmartCells, Inc., a private
biotech developing a glucose-responsive insulin whose
proof-of-concept preclinical trials were partially funded
by the Juvenile Diabetes Research Foundation (JDRF).
SmartCells' product ... is designed to be a once-a-day
injection that will maintain continuous, tight control of
blood glucose levels while reducing the risk of hypo-
glycemia - like the pancreas does automatically in
the absence of [any glucose anomaly] ...
.... From 2008 to 2010, JDRF provided significant finan-
cial support - a total of over $1.5 million in funding -
to the early-stage development of SmartInsulin (TM).
....
"Our funding to SmartCells was an important step in
what has become the JDRF Insulin Initiative," noted
Dr Sanjoy Dutta, Director of Glucose Control research
at JDRF. "We are focused on supporting an effort
towards the development of faster-acting insulins,
other glucose-responsive insulins and novel therapies
that will help people with diabetes [any one of the
High Glucose Conditions] maintain glucose control
[glucose levels akin to what people without a High
Glucose Condition maintain] with less effort [ideally,
far less effort, and a shot per day with *NO* blood-
pricks and *NO* hypoglycemic risks and *NO* hyper-
glycemic risks, wow, that would be grand, though
I doubt that is within the capability of the insulin
being tested in this particular effort]."
....
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Pro-Humanist FREELOVER
C.ure I.nsulinitis A.ssociation
http://prohuman.net/cureinsulinitisassociation.htm
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Postscript: High Glucose Conditions
Insulinitis (insulin production totally or near-totally
lost in the overwhelming majority of cases due to
an autoimmune attack on the pancreas; currently,
treated most often with multiple daily insulin injec-
tions or with an insulin pump and mulitiple daily
decisions regarding how much insulin to pump to
deal with changes in glucose levels which occur
due to eating, drinking, stress, exercise, other
medications, other diseases, and other metabolic
impacts on glucose levels)
Cellosis (in 75% of persons with Cellosis, exercise
and diet and oral medications are adequate to sup-
plement the continued but oft-times reduced pro-
duction of insulin in people with insulin resistance,
and insulin injections are only used in about 25%
of persons with Cellosis, and only after other treat-
ments fall short of keeping glucose levels within
acceptable ranges)
Diminosis (diminished insulin production due to a
monogenetic condition, and different treatments
are used based on the type of Diminosis; some
types are, in essence, curable, but proper diag-
nosis is often not made due to the expense of
doing the genetic testing required to diagnose
the condition)
Other High Glucose Conditions: The most frequent
one is a temporary consequence of pregnancy in
a small percent of pregancies, a temporary condi-
tion which disappears once the pregnancy ends,
that condition being Gestational Cellosis. Other
High Glucose Conditions exist, most often result-
ing from other diseases or from treatments for
other diseases.
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