Re: No Significant Benefit of Intensive Therapy in Diabetes
- From: Tim Shoppa <shoppa@xxxxxxxxxxxxxxxxx>
- Date: Mon, 4 Oct 2010 07:38:14 -0700 (PDT)
On Oct 4, 9:58 am, Chris Malcolm <c...@xxxxxxxxxxxxxxxxx> wrote:
But the changing
circumstances (the changing "usual treatment") rendered their results
statistically insignificant.
The DCCT (a T1 study) faced a similar challenge in the 80's. When it
started, the control group was not allowed home bg testing because
that was in the original definition "intensive". It changed early on
to adopt to the changine circumstances, and It produced many
stunningly convincing results regardless. And it also produced some
non-results, showing that intensive control doesn't help every
possible complication or co-morbidity. And it produced some results
that showed the dangers of intensive control too.
Today the relation between average bg and microvascular complications
like retinopathy, neuropathy, kidney disease may be obvious, but in
the 80's it wasn't... in fact some of my first docs believed that
insulin caused the complications.
Tim.
.
- References:
- No Significant Benefit of Intensive Therapy in Diabetes
- From: Kurt
- Re: No Significant Benefit of Intensive Therapy in Diabetes
- From: Janet
- Re: No Significant Benefit of Intensive Therapy in Diabetes
- From: Chris Malcolm
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