Low carb ? The best diet for you depends on your gene pool
- From: "GysdeJongh" <jongh711@xxxxxxxxx>
- Date: Sun, 4 Apr 2010 13:40:00 +0200
Which diet is best for you ?
That depends on what your genes do to the food after you have eaten it
all the discussions of the grass fed people about carb content might have missed a few points
DNA Testing Determines which Popular Diet Will Work
New data provided some early evidence that the secret to weight loss might lie in DNA and that the best way to shed excessive pounds is to diet according to genotype....
The new data are derived from a study the group previously conducted in 311 overweight women who were randomized to four popular diets: the very-low-carbohydrate Atkins diet, the low-carbohydrate Zone diet, the very-low-fat Ornish diet, and the low-fat LEARN diet. In that trial, known as the Atkins-Traditional-Ornish-Zone (A TO Z) study, women assigned to the Atkins diet had a modest benefit relative to the other diets, but overall results were disappointing in that the women, on average, lost only about 10 pounds.
"Within every diet group, though, some of the women lost more than 30 pounds and kept it off for over a year," said Gardner. "And some of the women gained more than 10 pounds. Within every diet, the range is at least 40 to 50 pounds. Between the different diets, the weight loss difference was just a few pounds, yet within the group, the difference is much larger. This is actually much more interesting than the difference between groups. How can the responses to the same diet be so different?"
With these data, the researchers were approached by Interleukin Genetics (Waltham, MA), asking them if they could obtain the DNA of the study participants. The company had previously identified three genes -- ABP2, ADRB2, and PPAR-gamma -- that could predict weight loss. These genes were shown to predict weight loss in three different studies, were biologically plausible, and were shown to have gene-diet interaction, said Gardner.
The researchers obtained DNA from 138 women and analyzed the weight loss according to genotype and diet in 133 participants. Among those participants who completed the 12-month study, researchers observed a significant interaction between diet assignment and weight loss after taking genotype pattern into consideration.
Women assigned to a genotype-appropriate diet lost 5.3% of their body weight compared with just 2.3% among those not matched to genotype (p=0.005). Within the Atkins group, for example, those appropriately assigned by genotype lost approximately 12 pounds compared with 2 pounds for those who lacked the low-carbohydrate genotype. In the Ornish group, similar reductions in weight were observed among those appropriately assigned by genotype.
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