OT : Liver Dump

Instead of a lot of separate posts, these are my answers to Alan, Chris,
Steve, Michael and others about this subject.I took it OT because I realise
this is a support group and not everyone is interested in technical details.

As a strange sidestep maybe :
if my brain has found a logical explanation for a situation than my soul
accepts it.So for me the technical details and the explanation itself is of
great comfort.Ymmv.

Here is my working definition of : Liver Dump :

It is an unexpected and large amount of glucose dumped by the liver in the
bloodstream.

Is Liver Dump equivalent of Gluconeogenesis ?
No, because Gluconeogenesisis a qualitative term, it is a description of
where the liver has made the glucose from.Gluconeogenesis is a metabolic
pathway that results in the generation of glucose from non-carbohydrate
carbon substrates such as lactate, glycerol, and glucogenic amino acids.

Is Liver Dump equivalent of Glycogenolysis
No, because Glycogenolysis is also a qualitative term, it is a description
of where the liver has made the glucose from.Glycogenolysis is the
catabolism of glycogen by removal of a glucose monomer through cleavage with
inorganic phosphate to produce glucose-1-phosphate.This derivative of
glucose is then converted to glucose-6-phosphate, an intermediate in
glycolysis.

So we can make a logical correct sentence like :
This morning I experienced a Liver Dump and my liver did it all by
Gluconeogenesis because I'm very low-carb and I my glycogen storage is
almost empty.Or : did it all by Glycogenolysis because I keep my glycogen
store filled by eating baklava.

In the morning the liver releases glucose in the bloodstream. Our circadian
rithm with the aid of its hormones makes us ready for the new day.This is
not a strange action of the liver.It happens also in healthy people.In T2
patients the bg rises because their muscles don't take the glucose up from
their bloodstream : which is called insulin resistance.So in my opinion Dawn
Effect is a much better term.It occurs only in the morning.The Dawn effect
is in the medical literature.

If you eat something then your liver should stop producing glucose, because
glucose is entering your blood stream via your intestines from the food you
are eating.This is caused the incretin effect.The incretin effect is a
feedback loop to the liver via GLP-1.In T2 the postprandial glucose peak is
mainly caused by the fact that in T2 the liver does not see the GLP-1
signal.This is called GLP-1 resistance.The liver also does not see other
feedback signals like leptin : Leptin resistance.In fact there are a zillion
possible causes....Both the incretin effect and leptin resistance are in the
medical literature.

In modern science the terms Gluconeogenesis and Glycogenolysis are nolonger
used.It is now appreciated that we are a vast interconnected web of
biochemical reactions.The new term is Metablomics : the total of all these
biochemical reactions.A few days ago I saw an article where it was proposed
to use Metablomic parameters instead of fingerprints to distinquish people
in the war on terrorism

Our metabolic reactions are more different then our finger prints !!! Ymmv
is thus very true of how you react to your food and medicine !!!!

There is a lot of literature on the continuous recording of blood glucose
and the graphs can be found on the internet.In those graphs there are only
peaks in the morning (dawn effect) and after eating (Post prandial peaks
caused by a not working incretin effect).This was also done for T2
patients.

In these graphs or in the medical literature there are no other large bg
peaks, so for me the term Liver Dump is a local mith : it does not exists.It
was invented in Asd.I change my mind of course if some one performs the
right experiments and shows me both all the data and the precise description
of his experiment.

hth
Gys

.

Relevant Pages

  • Re: Can there be an afternoon liver dump?
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  • Re: Researchers Discover Mechanistic Link Between High-Fat Diet and Type 2 Diabetes
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  • Re: OT : Liver Dump
    ... dump glucose even after eating in a T2? ... In order to correct a liver dump, you need to eat a little carb to shut off the liver's "help". ... the liver does not detect glucose levels; ... Is Liver Dump equivalent of Glycogenolysis ...
    (alt.support.diabetes)
  • Key regulator of blood glucose levels discovered
    ... Key regulator of blood glucose levels discovered ... blood sugar levels are high. ... liver cells. ... turns on the TORC2 switch and allows the liver to make more glucose. ...
    (alt.support.diabetes)
  • Re: Breakfast!
    ... High Miles wrote: ... but what the heck is a 'liver dump'? ... Your liver releases glucose into your bloodstream when it thinks you ...
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