Re: Saturated Fats and Metabolic Syndrome

"Quentin Grady" <quentin@xxxxxxxxxxxxxxx> wrote in message
news:8igel49osjnjbohg57l3f0psuf2tbo1hno@xxxxxxxxxx
On Sat, 27 Dec 2008 12:33:52 +0100, "GysdeJongh" <jongh711@xxxxxxxxx>


Hi Gys,
Is it possible the current article has changed?

Hi Quentin,
I'm not sure what you mean by that (?) The title of the article, the authors
and the university are the same as in the original POST by Randy.So I think
we are talking about the same article in this thread.Btw, I don't see ABC, I
don't see the cross POSTs either.I do see the contributions of Trig.Tha
could be the problem if you don't killfile those (?)

I'm trying to connect this to themes I've been following.

I consider you the expert on fat here :) I know you follow other themes and
threads on fat.I find the subject fat fascinating but unbelievable
complicated.I'm trying to find all relevant information since my dx in
2005.Fat is a survival factor , but it heavily depends on the environment
and other factors like : are you T2, do you exercise, are you overweight.All
factors that influence the fat-survival factor.I've seen your thread Playing
with milk fat.This is a recent breakthrough, seen it ?

http://www.sciencemag.org/cgi/content/abstract/322/5907/1539
Science. 2008 Dec 5;322(5907):1539-43.
A stress signaling pathway in adipose tissue regulates hepatic insulin
resistance.

A high-fat diet causes activation of the regulatory protein c-Jun
NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance.
JNK1 is therefore a potential target for therapeutic treatment of metabolic
syndrome. We explored the mechanism of JNK1 signaling by engineering mice in
which the Jnk1 gene was ablated selectively in adipose tissue. JNK1
deficiency in adipose tissue suppressed high-fat diet-induced insulin
resistance in the liver. JNK1-dependent secretion of the inflammatory
cytokine interleukin-6 by adipose tissue caused increased expression of
liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1
activation in adipose tissue can cause insulin resistance in the liver.

PMID: 19056984

An Epidemiological study, not on diabetic patients.Milk fat, other saturated
fats and eggs are all associated with Heart failure in a large population.So
this is not a secondary outcome like cholesterol or arterie stiffness..They
used the primary outcome "Heart Failure"........ :

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B758G-4TT89NH-K&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f629d4ee1336e383758cc406dd4b5126

J Am Diet Assoc. 2008 Nov;108(11):1881-7.
Incident heart failure is associated with lower whole-grain intake and
greater high-fat dairy and egg intake in the Atherosclerosis Risk in
Communities (ARIC) study.

BACKGROUND: Prospective studies evaluating associations between food intake
and risk of heart failure (HF) in diverse populations are needed.
OBJECTIVES: Relationships between incident HF (death or hospitalization) and
intake of seven food categories (whole grains, fruits/vegetables, fish,
nuts, high-fat dairy, eggs, red meat) were investigated in an observational
cohort of 14,153 African-American and white adults, age 45 to 64 years,
sampled from four US communities. METHODS: Between baseline (1987-1989) and
Exam 3 (1993-1995), dietary intake was based on responses to a 66-item food
frequency questionnaire administered at baseline; thereafter, intake was
based on averaged baseline and Exam 3 responses. Hazard ratios (HR [95% CI])
for HF were calculated per 1-daily serving difference in food group intake.
RESULTS: During a mean of 13 years, 1,140 HF hospitalizations were
identified. After multivariable adjustment (energy intake, demographics,
lifestyle factors, prevalent cardiovascular disease, diabetes,
hypertension), HF risk was lower with greater whole-grain intake (0.93
[0.87, 0.99]), but HF risk was higher with greater intake of eggs (1.23
[1.08, 1.41]) and high-fat dairy (1.08 [1.01, 1.16]). These associations
remained significant independent of intakes of the five other food
categories, which were not associated with HF. CONCLUSIONS: In this large,
population-based sample of African-American and white adults, whole-grain
intake was associated with lower HF risk, whereas intake of eggs and
high-fat dairy were associated with greater HF risk after adjustment for
several confounders.

PMID: 18954578

hth
Gys


.

Relevant Pages

  • Ba Tha(`ng DDoc To+` Na`y mo+i thu+.c su+. la` dzo^t ne` (except Dr. Tri)
    ... Low-salt diet ups risk of fatal heart attack? ... Low salt intake may increase risk of dying from heart attack or ... Also suggests that high sodium intake does not boost risk of ...
    (soc.culture.vietnamese)
  • Re: Why are pickled food bad for you?
    ... Chinese get massive rates of stomach cancer from pickled cabbage. ... What healthful properties kimchi may have are disputed, ... of gastric cancer risk, South Korean researchers uncovered a 50% ... used for flavoring may also be an issue, as high salt intake could ...
    (sci.med.nutrition)
  • Cold-water fish, hot questions ;)
    ... I sometimes like to eat fresh salmon or mackerel with all the skin. ... a minimum intake of eicosapentaenoic ... healthy adults were estimated and the subsequent risk for death from ... reduce risk for death from CHD in healthy adults. ...
    (sci.med.nutrition)
  • Re: the business of carbs or is it the conspiracy or carbs?
    ... Whole-grain and fiber intakes and periodontitis risk in men.' ... Men in the highest quintile of whole-grain intake were 23% less ... so-called whole grains as opposed to more refined grains also tend to brush ... Serum homocysteine concentrations were lower with greater ...
    (sci.med.nutrition)
  • Re: obese chinese kids eat fewer carbs
    ... When women in the highest quintile of energy-adjusted total fat intake were compared with women in the lowest quintile, the multivariate pooled relative risk of breast cancer was ...
    (sci.med.nutrition)