Re: Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction

It didn't ask this question. Nor am I a fan of
meta-analysis or for that matter Cochrane reviews.

Correlation is OK but I wanted more in terms of
mechanism, in vitro work, etc. I suppose I should
have done my own search for the desired insights.

don't conflate, please I say to Jong.............Trig

On Dec 12, 2:16 am, "GysdeJongh" <jongh...@xxxxxxxxx> wrote:
"Nicky" <ukc802466...@xxxxxxxxxxxxx> wrote in message

news:7494k41aledk7ojsih53o6ibtb8blf51a3@xxxxxxxxxx

On Thu, 11 Dec 2008 11:26:13 -0800 (PST), "trigonometry1...@xxxxxxxxx
|" <trigonometry1...@xxxxxxxxx> wrote:
Is there a meta-review of vit D supplementation, anyone know?

At your service  :)

Last free Review :http://jcem.endojournals.org/cgi/reprint/92/6/2017
J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27.
The role of vitamin D and calcium in type 2 diabetes. A systematic review
and meta-analysis.Pittas AG, Lau J, Hu FB, Dawson-Hughes B.

CONTEXT: Altered vitamin D and calcium homeostasis may play a role in the
development of type 2 diabetes mellitus (type 2 DM). EVIDENCE ACQUISITION
AND ANALYSES: MEDLINE review was conducted through January 2007 for
observational studies and clinical trials in adults with outcomes related to
glucose homeostasis. When data were available to combine, meta-analyses were
performed, and summary odds ratios (OR) are presented. EVIDENCE SYNTHESIS:
Observational studies show a relatively consistent association between low
vitamin D status, calcium or dairy intake, and prevalent type 2 DM or
metabolic syndrome [OR (95% confidence interval): type 2 DM prevalence, 0..36
(0.16-0.80) among nonblacks for highest vs. lowest 25-hydroxyvitamin D;
metabolic syndrome prevalence, 0.71 (0.57-0.89) for highest vs. lowest dairy
intake]. There are also inverse associations with incident type 2 DM or
metabolic syndrome [OR (95% confidence interval): type 2 DM incidence, 0.82
(0.72-0.93) for highest vs. lowest combined vitamin D and calcium intake;
0.86 (0.79-0.93) for highest vs. lowest dairy intake]. Evidence from trials
with vitamin D and/or calcium supplementation suggests that combined vitamin
D and calcium supplementation may have a role in the prevention of type 2 DM
only in populations at high risk (i.e. glucose intolerance). The available
evidence is limited because most observational studies are cross-sectional
and did not adjust for important confounders, whereas intervention studies
were short in duration, included few subjects, used a variety of
formulations of vitamin D and calcium, or did post hoc analyses.
CONCLUSIONS: Vitamin D and calcium insufficiency may negatively influence
glycemia, whereas combined supplementation with both nutrients may be
beneficial in optimizing glucose metabolism.

PMID: 17389701
PMCID: PMC2085234

For more (reviews) Click the related article links in Pubmed here :http://www.ncbi.nlm.nih.gov/pubmed/17389701?dopt=Citation

Dr William Davis, a cardiologist,  is a great advocate of Vit D
supplements.Here is his last blog :http://heartscanblog.blogspot.com/2008/12/another-case-of-aortic-valv...

Thursday, December 11, 2008

Another case of aortic valve disease reduced with vitamin D

I watched Seth's aortic valve deteriorate over a two year period. I was
first consulted in 2004 to offer an opinion on Seth's heart scan score of
779 and flagrantly abnormal cholesterol patterns, including triglycerides in
the 400 mg/dl range. But I heard a murmur, as well, a murmur of a leaky
aortic valve, "aortic valve insufficiency."   Over the next two years, I
watched Seth's aortic valve worsen, going from mild leakiness to severe.
In 2006-2007, I tiptoed into vitamin D replacement and asked Seth to add
some vitamin D. Time passed and Seth's aortic valve got progressively worse.
Over the past year, However, he's maintained a truly healthy level of
vitamin D, with blood levels consistently in the 60-70 ng/ml range.   While
Seth's last echocardiogram showed a severely leaky aortic valve, the most
recent echo showed mild leakiness ("mild aortic insufficiency")--a dramatic
reduction.   I continue to see this in many, though not all, patients with
aortic valve disease. Though I've more frequently witnessed either stalled
progression or reversal of aortic valve stenosis (stiffness), I've now seen
a handful of people with aortic valve leakiness (insufficiency) also
reverse.   I've posted about this peculiar phenomenon previously:  Aortic
valve disease and vitamin D More on aortic valve disease and vitamin D
Prior to vitamin D, I had NEVER witnessed any aortic valve disease stop or
reverse.   A formal trial at some point would be invaluable.

hth
Gys

.

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