Re: Lipids, Carbs, Statins and all that.
- From: Quentin Grady <quentin@xxxxxxxxxxxxxxx>
- Date: Mon, 27 Oct 2008 09:34:08 +1300
Thank you Gys,
It is a fascinating opinion piece by a doctor. People in such
positions have the opportunity to make many observations if they've a
mind to.
Opinions do differ as to whether fish oil alters the risk of further
heart attacks. The consensus seems to be that taking fish oil
capsules doesn't help in that particular circumstance. Maybe they have
some preventative function for those who haven't had a heart attack.
The one thing that is clear is that omega-3 in the form of canola
appears to be effective.
Best wishes and thank you,
Quentin,.
On Sun, 26 Oct 2008 16:11:49 +0100, "GysdeJongh" <jongh711@xxxxxxxxx>
wrote:
"Alan S" <loralgtweightandcarbs@xxxxxxxxx> wrote in message--
news:mcn4g4l7248333pg7vrke17sg6hm049qs9@xxxxxxxxxx
G'day All
I just wrote an answer to a person on the ADA forum with a
collection of random thoughts on Lipids, Carbs, Statins and
all that. I'll repeat it below, because I respect the
opinions of those here on this subject.
I don't pretend to be an expert, just that I've read a lot
about it. Often the information is conflicting, so I try to
make sense out it in my own way.
Hi Alan,
do you know the Heart Scan Blog of William Davis ?
http://www.blogger.com/profile/13560720596936850117
I have his rss-feed, he is a cardiologists and I like his views on carbs and
blood cholesterol values.He are a few links.I think you will like his blog
entitled "Wheat withdrawal: How common?" :)
http://heartscanblog.blogspot.com/2008/10/wheat-withdrawal-how-common.html
I counsel many patients to consider the elimination of wheat, as well as
cornstarch products, in an effort to regain control over:
--Weight
--Appetite
--Low HDL
--High triglycerides
--Small LDL
--High blood sugar
--High blood pressure
All of these issues respond--often dramatically--to elimination of wheat and
cornstarch.
Why would there be undesirable effects of eliminating wheat?
One clear issue is that elimination of wheat and other sugar-equivalents
deprives your body of glucose. Your body then needs to resort to fatty acid
metabolism to generate energy. Apparently, some people are inefficient at
this conversion, having subsisted on carbohydrates for the last few decades
of their lives. However, as fatty acid metabolism kicks in, energy
generation improves. That is my (over-)simplified way of reasoning it
through.Whatever the mechanism, I find it very peculiar that this food
widely touted by the USDA, American Heart Association, and other agencies
actually triggers a withdrawal syndrome in approximately 25% of people.
Spinach does not trigger withdrawal. Nor does flaxseed, olive oil, almonds,
and countless other healthy foods.
http://heartscanblog.blogspot.com/2008/10/does-fish-oil-add-to-statin-therapy.html
Does fish oil ADD to statin therapy?
Yet another patient came to my office today saying, "My primary doctor said
that I should stop taking fish oil. He say's that I don't need it because I
take Crestor."The woman was in tears, confused and frightened over a
potential disagreement between her doctors.Is this true? If someone takes a
statin drug, like Crestor, Lipitor, Zocor (simvastatin), pravachol, or
lovastatin, they don't need to take anything else because the statin drug is
so powerful that it eliminates risk?No. Not even close to the truth.First of
all, let's accept that virtually the entire body of statin drug
literature--hundreds of studies, billions of dollars spent--was paid for by
the drug industry.What are the incremental benefits of adding omega-3 fatty
acids from fish oil added to statins? The best data originate with the JELIS
Trial (Effects of eicosapentaenoic acid on major coronary events in
hypercholesterolaemic patients (JELIS): a randomised open-label, blinded
endpoint analysis), in which 19,000 Japanese participants (who already have
a high omega-3 intake from diet, usually ranging from 1800-3000 mg per day)
experienced a 19% reduction (relative reduction) in cardiovascular
events.GISSI Prevenzione demonstrated a 28% reduction in heart attack, 45%
reduction in death from heart attack with fish oil.
Omega-3 fatty acids from fish oil also:
--Reduce triglycerides dramatically
--Accelerate after-eating clearance of digestive by-products, i.e., they
correct post-prandial abnormalities
--Modify the character (fragmentation potential, structural strength) of
plaque
--Raise HDL modestly
If you buy your fish oil from Sam's Club, Costco, or other discounter, a
healthy dose of fish oil might cost you $3 per month. Compare that to the
$120 per month average cost of a statin agent. Why is there even a
discussion over this?
Like here he frequently gives references to the literature.
http://heartscanblog.blogspot.com/2008/10/hdl-h-is-for-happy.html
HDL: "H" is for "happy"What role do emotions play in HDL cholesterol?I've
often observed a peculiar phenomenon: People who come to the office or
hospital in the midst of a difficult emotional situation?e.g., stress at
home, financial struggles, hospitalization (usually an unhappy occasion)?
can show dramatic drops in HDL cholesterol. Not uncommonly, HDL drops 20 or
more mg/dl.
http://heartscanblog.blogspot.com/2008/10/does-high-cholesterol-cause-heart.html
Does high cholesterol cause heart disease?How often does someone develop
coronary heart disease from high cholesterol alone?Believe drug industry
propaganda and you'd think that everyone does. Physicians have bought into
this concept also, driving the $27 billion annual sales in statin
cholesterol drugs.In my experience, I can count the number of people who
develop coronary disease from high cholesterol alone on one hand. It
happens--but rarely.
"Q. Can you tell me why low carb helps cholesterol?
How many do you want ?
I just found 188 hits in my own Database on "cholesterol"
Here is a recent one (17-7-2008) :
BACKGROUND: Trials comparing the effectiveness and safety of weight-loss
diets are frequently limited by short follow-up times and high dropout
rates. METHODS: In this 2-year trial, we randomly assigned 322 moderately
obese subjects (mean age, 52 years; mean body-mass index [the weight in
kilograms divided by the square of the height in meters], 31; male sex, 86%)
to one of three diets: low-fat, restricted-calorie; Mediterranean,
restricted-calorie; or low-carbohydrate, non-restricted-calorie. RESULTS:
The rate of adherence to a study diet was 95.4% at 1 year and 84.6% at 2
years. The Mediterranean-diet group consumed the largest amounts of dietary
fiber and had the highest ratio of monounsaturated to saturated fat (P<0.05
for all comparisons among treatment groups). The low-carbohydrate group
consumed the smallest amount of carbohydrates and the largest amounts of
fat, protein, and cholesterol and had the highest percentage of participants
with detectable urinary ketones (P<0.05 for all comparisons among treatment
groups). The mean weight loss was 2.9 kg for the low-fat group, 4.4 kg for
the Mediterranean-diet group, and 4.7 kg for the low-carbohydrate group
(P<0.001 for the interaction between diet group and time); among the 272
participants who completed the intervention, the mean weight losses were 3.3
kg, 4.6 kg, and 5.5 kg, respectively. The relative reduction in the ratio of
total cholesterol to high-density lipoprotein cholesterol was 20% in the
low-carbohydrate group and 12% in the low-fat group (P=0.01). Among the 36
subjects with diabetes, changes in fasting plasma glucose and insulin levels
were more favorable among those assigned to the Mediterranean diet than
among those assigned to the low-fat diet (P<0.001 for the interaction among
diabetes and Mediterranean diet and time with respect to fasting glucose
levels). CONCLUSIONS: Mediterranean and low-carbohydrate diets may be
effective alternatives to low-fat diets. The more favorable effects on
lipids (with the low-carbohydrate diet) and on glycemic control (with the
Mediterranean diet) suggest that personal preferences and metabolic
considerations might inform individualized tailoring of dietary
interventions. (ClinicalTrials.gov number, NCT00160108.)
Pubmed : 18635428
hth
Gys
Quentin Grady ^ ^ /
New Zealand, >#,#< [
/ \ /\
"... and the blind dog was leading."
http://homepages.paradise.net.nz/quentin
.
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