Re: Ping: Louise

Susan wrote:
x-no-archive: yes


Biol Psychiatry. 2006 Dec 15;60(12):1343-9. Epub 2006 Aug 4. Links

Comment in:
Biol Psychiatry. 2008 Jan 1;63(1):e1; author reply e3.
Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression.
DeBattista C, Belanoff J, Glass S, Khan A, Horne RL, Blasey C, Carpenter LL, Alva G.
Corcept Therapeutics, Menlo Park, California, USA. debattista@xxxxxxxxxxxx

BACKGROUND: Abnormalities in the hypothalamic pituitary adrenal axis have been implicated in the pathophysiology of psychotic major depression (PMD). Recent studies have suggested that the antiglucocorticoid, mifepristone might have a role in the treatment of PMD. The current study tested the efficacy of mifepristone treatment of the psychotic symptoms of PMD. METHODS: 221 patients, aged 19 to 75 years, who met DSM-IV and SCID criteria for PMD and were not receiving antidepressants or antipsychotics, participated in a double blind, randomized, placebo controlled study. Patients were randomly assigned to either 7 days of mifepristone (n = 105) or placebo (n = 116) followed by 21 days of usual treatment. RESULTS: Patients treated with mifepristone were significantly more likely to achieve response, defined as a 30% reduction in the Brief Psychiatric Rating Scale (BPRS). In addition, mifepristone treated patients were significantly more likely to achieve a 50% reduction in the BPRS Positive Symptom Scale (PSS). No significant differences were observed on measures of depression. CONCLUSION: A seven day course of mifepristone followed by usual treatment appears to be effective and well tolerated in the treatment of psychosis in PMD. This study suggests that the antiglucocorticoid, mifepristone, might represent an alternative to traditional treatments of psychosis in psychotic depression.
PMID: 16889757 [PubMed - indexed for MEDLINE]



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For clarification - I'm on the BP spectrum, non-psychotic, diagnosed BPII
.

Relevant Pages

  • Re: Ping: Louise
    ... Abnormalities in the hypothalamic pituitary adrenal axis have been implicated in the pathophysiology of psychotic major depression. ... Recent studies have suggested that the antiglucocorticoid, mifepristone might have a role in the treatment of PMD. ... A seven day course of mifepristone followed by usual treatment appears to be effective and well tolerated in the treatment of psychosis in PMD. ...
    (alt.support.diabetes)
  • Ping: Louise
    ... Abnormalities in the hypothalamic pituitary adrenal axis have been implicated in the pathophysiology of psychotic major depression. ... Recent studies have suggested that the antiglucocorticoid, mifepristone might have a role in the treatment of PMD. ... A seven day course of mifepristone followed by usual treatment appears to be effective and well tolerated in the treatment of psychosis in PMD. ...
    (alt.support.diabetes)
  • I dont feel depressed
    ... began treatment! ... Nothing I feel could be called "depression" by me. ... is the same with psychosis. ... I knew something was wrong last summer when I started antidepressants again, ...
    (uk.people.support.depression)
  • !Why the VA Tech shooter was not committed. [A Must Read.]
    ... Not only wasn't psychosis a bad thing, ... treatment was never called for. ... Many of these unfortunates end up as victims of violent crimes. ... Which brings us to outrages such as the Virginia Tech massacre. ...
    (alt.politics)
  • Re: Yuck!!!
    ... It doesn't usually taste of anything except ... I've got Psychotic Depression and the Zyprexa has kept the ... Psychosis is a real pain in the arse. ... I hope the peeps on Paroxetine aren't as bad as my imagination is ...
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