Re: Water Pump Replacement (not OT)

"hemyd" <myd!!!hen@xxxxxxxxxxxxxxx> wrote in message
news:484b142d$0$30462$afc38c87@xxxxxxxxxxxxxxxxxxxxxxx


I am puzzled - why relatively not-physically stressful work could have a
bigger effect in lowering my bg that more physically stressful work.

Hi hemyd,
glucose is used as an energy carrier by the human body.Unfortunately free
glucose is toxic so the glucose is transported at an unbelievable low
concentration which must be very precisely regulated.

Insulin is a hormone.It is a master switch.It does not transport glucose.It
is the "bossy manager" which tells the muscle cells to come from the couch
and start scooping up the glucose.

However...
Insulin also signals your body that there is energy which should be stored
for later use as glycogen but preferably as fat.Fat is the most efficient
form of energy storage because it has more calories per weight.If there is a
lot of carbohydrate than insulin signals the body to convert it to fat !

Insulin also directly signals your brain that life is beautiful.This
function of insulin is conserved in evolution and even present in the
fruitfly.The human brain has a lot of insulin receptors which provide the
brain information about the feeding status of your body.The feeding status
of your body is also "measured" by nerve signals from your intestine (which
is why bariatic surgery is working or even a plastic sleeve
http://www.medpagetoday.com/MeetingCoverage/ADA/tb/9759 ) from your stomag
, from your liver ,etc , etc.All those signals are integrated in your
hypothalamus and than feedback to your liver (and other organs) or it causes
the release of the hormone grehlin making you so agressive for food that you
can kill a dinosaur.

Rough calculation :
6 mmol/l glucose in your blood ; 5 l blood => 6 x 5 = 30 mmol glucose
..Molecular weight of glucose = 180. So 30 mmol glucose = 30 / 1000 * 180 =
5.4 g glucose. Glucose is a carbohydrate so 4 Cal/g . Or in your blood is a
total of : 5.4 x 4 = 20 calories. You need 2000 calories per day , or 2000
/24 = 80 calories per h in total.Your large brain consumes 20% !!!!! of your
energy.Evolution pays this price because it proved to be worth ; the
dinosaur died out because humans hunted it to extinction.Speers and
cooperation made posssible by their large brains.Or your brain needs 80 x 20
/ 100 = 16 cal / h

So your brain runs about 20 / 16 = 1 h on the glucose present in all your
blood...... What happens of course is that the signalling network will
restore the glucose concentration in your blood if it falls only slightly
below the set point of 6 mmol/l.That is if all is functioning correctly.....
If the signalling network is broke than it depends on where the fault is
what will happen of course....

Your brain is a very mighty and selfish organ.It will command your liver via
a direct nerve link to make glucose and dump it in your blood.If there is no
glycogen or fat than your muscle is broken down....The strange thing is that
your brain wants to run on glucose.But by "brain" most people mean their
consious brain , the nerve cells or neurons which alow them to type things
in alt.support.diabetes.Those neurons run on ketone bodies , lactate and
beta hydroxy butyrate.The organ in your skull consists of a lot of different
cells behind the blood/brain barrier.The astrocytes there were once
considered as just the structure,now they are regarded as a sort of nursing
cells for your neurons.Glucose crosses the blood / brain barrier by passive
diffusion , is transported into the astrocytes , converted to ketone bodies
and than handed over to the neurons for the production of ATP, energy.... I
find it comforting to know that my contributions to asd are made by the
stuff in olive oil , wallnuts and salmon and not by rice , not even by brown
rice :)

If you think hard what happens ? Do you use more energy ???
No you don't !
This question is very difficult to answer
The debate is going on
In the mean time it's like my computer it uses x watts if I just stare at
its desktop but is also uses x wats if I load Matlab and calculate the eigen
structure of a large matrix.The cpu goes from 0 to 100 % but it still
consumes x watt.Here is a recent experiment which is free if you want to
know the details :

http://www.ncbi.nlm.nih.gov/pubmed/18321731?dopt=Citation

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18321731

Neuroimage. 2008 May 1;40(4):1460-8. Epub 2008 Feb 1.
The cortical energy needed for conscious perception.

The brain's information processing power is limited by its energy supply but
the allocation of cortical energy use between conscious and unconscious
information processing is unknown. We calculate, from electrophysiological
data in primates, that conscious perception reflects surprisingly small
local alterations in mean cortical neuronal firing rate and energy
consumption: perceiving visual stimulus movement, altered tactile vibration
frequency, or tone stream separation, changes local cortical energy use by
less than 6%. Our estimations of energy use suggest that a "design
strategy", of encoding signals using separate neurons that increase and
decrease their firing rate, serves to minimise changes of energy use in the
cortical areas mediating perception and may result in stimulus perception
failing to be detected by BOLD functional imaging.

PMCID: PMC2330065

So thinking hard to repair the water pump did not increase the energy need
for your , consious , brain.My guess : you got interested in the problem you
got more adrenalin in your blood and your body got in the flee or fight mode
to kill the dinosaur.The signalling network in your body should have coped
with all the details like the amount of glucose and insulin needed to do the
job.What happend to you depends of course on where and what part of your
signalling network is not working optimally....

hth
Gys

















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