Re: Anecdote re: effect of adrenal function on post prandial bg

On Fri, 30 May 2008 16:41:08 -0400, Susan <nevermind@xxxxxxxxxx>
wrote:

x-no-archive: yes

Trinkwasser wrote:

One of the things that occurs is that her BG increases (though so far
not to diabetic levels) while on the pred, and has been dropping back
to normal again while off it. Maybe I should creep up on her and do
some more regular testing.

So do keep posting, you never know who you might be helping

I agree that your mother, at this point, has adrenal insufficiency or
suppression caused by Prednisone, but treating it with Pred is a bad
idea. It's too strong and the half life is too long, so it ends up
doing more harm than good over time. If you dose in the morning, you
suppress the HPA for 12 hours, I've read. If you dose at night, you
suppress for 24 hours. Pred has a very long half life, so doses are
overlapping each day for full time suppression.

She's tried dropping the dose below what she's currently on, but
starts getting the return of the symptoms. Nevertheless they may try
some more tweaking later if she remains as stable as she has been. I
think they were tapering her off far too fast.

She'd be better off with hydrocortisone, say, 20 mg in the a.m. and 5
mg. at 2 p.m. or 4 p.m. for a fast acting, fast clearing adrenal support
with a short half life that's much more like physiological cortisol.

Before long, DuoCort should be on the market to treat AI; it's a time
released drug that is released in a normal diurnal rhythm, highest in
the a.m. to a nadir at midnight.

Hmmm, if it's that new it'll be expensive, pred is cheap as chips, no
prizes for guessing what her future treament will be . . .
.

Relevant Pages

  • Re: Anecdote re: effect of adrenal function on post prandial bg
    ... I agree that your mother, at this point, has adrenal insufficiency or suppression caused by Prednisone, but treating it with Pred is a bad idea. ... It's too strong and the half life is too long, so it ends up doing more harm than good over time. ... If you dose in the morning, you suppress the HPA for 12 hours, I've read. ... Before long, DuoCort should be on the market to treat AI; it's a time released drug that is released in a normal diurnal rhythm, highest in the a.m. to a nadir at midnight. ...
    (alt.support.diabetes)
  • Re: beta-blockers
    ... I'm dropping it with my doctor's blessing but over a four week period. ... to take half a dose for a while and then nothing. ... Resting pulse slowly came down close to ... No, I took 25 mg yesterday afternoon at 3pm, when I always take it. ...
    (sci.med.cardiology)