Re: New effect for insulin discovered


"dumb_fishie99" <dumb_fishie99@xxxxxxxxx> wrote in message
news:d5ad1b53-179d-4805-9e7a-baf32365e59c@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
On Apr 3, 11:10 am, Uncle Enrico <Un...@xxxxxxxxxx> wrote:
RodS wrote:

New effect for insulin discovered

Researchers at the Joslin Diabetes Center have shown that insulin has a
previously unknown effect that plays a role in aging and lifespan, a
finding that could ultimately provide a mechanism for gene manipulations
that could help people live longer and healthier lives.

Full Article here:

http://tinyurl.com/37yltz

All of which speaks well for avoiding overeating, avoiding weight gain
over the normal, reduction of insulin resistance, and avoidance of too
much circulating insulin.

But we already knew that.

It was interesting to find out that metformin is good for anti-aging:

http://www.lef.org/magazine/mag2003/2003_preprint_bio_02.html

Metformin stands out from the pack


The BioMarker scientists found that all the glucoregulatory agents
reproduced some of the gene expression effects of CR, but that
metformin was the undisputed star of the group, being twice as
effective as the others in reproducing the effects of CR. The
chemopreventive agent reproduced almost none of the effects of CR.
Fig. 4 summarizes the gene expression changes. The overlap between the
drug-induced gene expression profiles and those of CR is represented
by the length of the colored bars.

(Fig. 4. The ability of drugs to mimic the gene expression effects of
caloric restriction. BioMarker scientists found that metformin was
most effective at reproducing the gene expression biomarkers of CR.
Metformin's ability to do so is represented at 100% by the lowest bar
in the chart, with the other drugs represented according to their
lesser ability to mimic CR relative to metformin. )



The genes that were altered in expression by both metformin and CR are
linked to drug metabolism and detoxification; energy metabolism;
protein biosynthesis and degradation; cell growth and proliferation
and the cytoskeleton. These findings suggest that metformin has more
beneficial effects than the reduction of blood glucose and insulin,
and that it may be an authentic anti-aging therapy.

Metformin extends life span

Further evidence that metformin is an anti-aging therapy is a study
conducted by scientists at the National Institute on Aging (NIA)
showing that metformin extended the life span of mice by 20%. The
results of this study were presented in November 2002 at an NIA-
sponsored meeting at the Mayan Ranch in Bandera, Texas. BioMarker is
now conducting a life span study with metformin to see if the company
can reproduce these results.

---------------------------------------
Could one of you please summarize this in plain talk. I am interested on
what injecting large quantities of insulin (over 100 units/day) will have on
me. Because of high insulin resistance a lot of insulin is required to
manage my BG's.


.

Relevant Pages

  • Re: New effect for insulin discovered
    ... finding that could ultimately provide a mechanism for gene manipulations ... much circulating insulin. ... It was interesting to find out that metformin is good for anti-aging: ... Fig. 4 summarizes the gene expression changes. ...
    (alt.support.diabetes)
  • Re: New effect for insulin discovered
    ... finding that could ultimately provide a mechanism for gene manipulations ... It was interesting to find out that metformin is good for anti-aging: ... Fig. 4 summarizes the gene expression changes. ... most effective at reproducing the gene expression biomarkers of CR. ...
    (alt.support.diabetes)
  • Re: Food, not drugs?
    ... Dietary carbohydrate modification induces alterations in gene ... carbohydrate modifications-a rye-pasta diet characterized by a low ... postprandial insulin response and an oat-wheat-potato diet ... characterized by a high postprandial insulin response-affect gene ...
    (alt.support.diabetes)
  • gene found that causes insulin resistance
    ... Diabetes Advance: Researchers Find Gene That Causes Resistance to ... new gene, called Insulin Receptor Substrate 1, doesn't affect ... whose work will be published in Nature Genetics Sept. 6. ...
    (alt.support.diabetes)
  • The quest to crack the genetic code of gene expression
    ... Cracking The Genetic Code For Control Of Gene Expression ... Molecular biologists, ... sequence for several species, for example mouse, dog, cow and chicken, ...
    (sci.bio.evolution)
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