Re: Data on negative outcomes of High Protein Low Carb diets (was diabetes treatments of yesterday)


<randy@xxxxxxx> wrote in message
news:1193587908.728664.139140@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Here's some recent data on negative outcomes of "Low Carb, High
Protein" diets.


1. Large Prospective Studies.

European Journal of Clinical Nutrition (2007) 61, 575-581
Full paper available here -
http://www.nature.com/ejcn/journal/v61/n5/pdf/1602557a.pdf

Conclusion: Prolonged consumption of diets low in carbohydrates and
high in
protein is associated with an increase in total mortality.

Hi Randy,
thanks for posting this interesting topic
I would like to comment on this reference :

Eur J Clin Nutr. 2007 May;61(5):575-81. Epub 2006 Nov 29
Low-carbohydrate-high-protein diet and long-term survival in a general
population cohort.
PMID: 17136037

Quote :
We have further probed exposure response by calculating mortality ratios
according to categories of LC/HP score (energy-adjusted components), rather
than assessing, as previously performed an underlying linear trend. We have
used as referent the group of study participants with score p6. The
mortality ratio was 1.20 for score between 7 and 9 (CI, 0.89-1.62), whereas
for score between 10 and 12 the ratio was 1.42 (CI, 1.06-1.89), for score
between 13 and 15 the ratio was 1.56 (CI, 1.13-2.13) and for score X16 the
ratio was 1.71 (CI, 1.22-2.41). Thus, the categorical data are consistent
with the trend data.
Un Quote

Their LC/HP index is a ratio it runs from 2 till 20
2 means : High Carb _AND_ Low protein
20 means Low Carb _AND_ High Protein
The LC/HP index is corrected for :
Total energy
gender
age
education
smoking
body mass index
exercise
alcohol consumption
saturated lipids
un saturated lipids

So starting only at scores between 13 and 15 the mortality ratio becomes
worrisome for me.YMMV.Because only at the end of the scale the confidence
limits do no longer include the no effect .The effect can be demonstrated if
your way of eating is very high in protein over an extended period of time
and even then it is small.

For me it is still important to find out what the actual biological
mechanism might be.But for that we have the feed animals one group with very
high carbohydrate and one group with very high protein ; both the same
Calories and see what happens. Or , more ethically , cell cultures with low
glucose or high aminoacids and do a expression profiling.

Quote :
In complementary analyses, we have run models 1-4 among Greek EPIC
participants who, at enrolment, had either coronary artery disease or
diabetes mellitus, as indicated in the Subjects and methods section. For a
two unit increase in the LC/HP score (absolute values), the mortality ratios
were: for coronary artery disease 1.18 (CI, 0.97-1.43) and for diabetes
mellitus 1.27 (CI, 1.02-1.59). For a two-unit increase in the LC/HP score
(energy -adjusted components), the corresponding ratios were 1.05 (CI, 0.96-
1.14) and 1.06 (CI, 0.95-1.17). Thus, the results in the three study groups
are consistent.
Un Quote

So for a 2 unit increase of the energy adjusted LC/HP score the mortality
ratio for diabetic patients 1.06 (CI, 0.95-1.17) and the confidence limits
still include the no effect.This does not worry me.YMMV.This is very
interesting because it states that carbohydrates are good for you but only
if you have no heart disease or diabetes !!!!I actually have some other
literature to confirm this :

Br J Nutr. 2007 Sep 10;:1-9
Effect of the LoBAG30 diet on blood glucose control in people with type 2
diabetes.
Nuttall FQ, Schweim K, Hoover H, Gannon MC.

In conclusion, a high-protein, 30 % carbohydrate diet could be a
patient-empowering method of improving the hyperglycaemia of type 2 diabetes
without pharmacologic intervention. Long-term effects and general
applicability of this diet remain to be determined.

PMID: 17868489

For me it is nice to see that the long term effects , assessed in a free
living population over many years , are small or even not significant

Quote:
The biology that underlines the positive association of LC/HP diets with
overall mortality is not clear. It appears that high protein intake may be
as important as low-carbohydrate intake and the results of a recent study
(Kelemen et al., 2005) point to the same direction. Moreover, the apparent
detrimental effect of the LC/HP diet should not be unexpected, in view of
the fact that dietary scores that have been reported to be associated with
reduced mortality are to a large extent 'mirror idols' to the LC/HP diets
(McCullough et al., 2002; Trichopoulou et al., 2003). In fact, the Nutrition
Committee of the Council on Nutrition, Physical Activity, and Metabolism of
the American Heart Association has stated that high protein diets are not
recommended because they restrict healthful foods (St Jeor et al., 2001).
UnQuote

This makes sense to me.In groups of healthy people there are associations
between eating carbohydrate , lots of exercise and a healthy body weight
which is sustained over a longer period.This was found in the National
Weight Control Registry : http://www.nwcr.ws/ .For me this is a brilliant
concept it just observes the pople who could do it ; just learn from the
proven experts :)

Thanks for the discussion
Gys


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