Re: Sorbinil

Jackie Patti <jpatti@xxxxxxxx> wrote:
GysdeJongh wrote:

One of the theories ( but this is just one of them) goes like this :
Glucose is transported into the (nerve)cell by insulin.Inside the cell the
glucose is converted to usefull things and energy.The technical name for the
way this is done is called : "The Polyol Pathway".The first step in this
Polyol Pathway is the conversion of Glucose to Sorbitol.This conversion is
done by an enzyme , like every thing else in your body is done by "an
enzyme".This particular enzyme is called : " Aldose Reductase". So Aldose
Reductase makes Sorbitol from Glucose.Sofar so good.Glucose comes from your
food but if you do not eat it your body just makes it itself.Sorbitol is
also in chewing gum but if you don't eat it your body quite hapily makes it
itself.

If T2D , like we , then there was (is) a chronic high glucose concentration
in the blood : hyperglycemia.This chronic too high bg will cause a chronic
too high glucose concentration inside the (nerve) cells.Thus there will be a
too high concentration of Sorbitol inside the cell.

Ummm...no. You don't get too high concentrations of glucose byproducts
inside the cell because the very fact of hyperglycemia means the glucose
doesn't get inside the cells. The whole problem with diabetes is the
glucose stays in the blood and therefore DOESN'T get in the cells, or
more accurately, gets into them much more slowly than in a nondiabetic.

I don't know much about the sorbitol stuff, but your argument is
incorrect at this point and therefore the rest of it can't quite make
sense since this bit is off.

The main thing wrong with the argument is that osmotic pressure is not
determined by the differential ratios of just one solute, but by the
total of all on each side of the membrane.

--
Chris Malcolm cam@xxxxxxxxxxxxxxxxxxxx DoD #205
IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

.

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