New Joslin Research/Fat Production

http://joslin.org/1083_4105.asp

New Joslin Research Identifies Sirtuin Protein Instrumental in Fat
Production and Metabolism
Finding may lead to new drugs to combat obesity and reduce diabetes
incidence

(excerpt)

BOSTON--August 15, 2007--A new Joslin Diabetes Center-led study has
identified a protein found in fat cells that may play a major role in
how fat is produced and stored, offering a new target for treatments
to prevent obesity and reduce the risk for type 2 diabetes. This
latest research appears in the August 2007 issue of Cell Metabolism.

The study examined the role of a protein called Sirt2, a member of the
sirtuin family of seven cellular proteins. These proteins have
recently been shown to be important in the control of aging and
metabolism. Previous studies have focused on one member of this
family, Sirt1, which is activated by high doses of resveratrol, a
substance found in red grapes, which can prevent diabetes from
developing and also prolong life. This finding generated tremendous
attention, leading biotechnology and pharmaceutical companies to begin
developing drugs and supplements to harness this effect. Joslin
researchers have focused on other sirtuin proteins to find out what
role they might play in fat and glucose metabolism and fat
development.

This is an important goal since more than 60 percent of Americans are
now overweight or obese, and obesity is a major factor driving the
current epidemic of type 2 diabetes, which now affects more than 20
million people in the U.S. alone.

.

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