vinegar & glycogen stores

I have been drinking 2 tbsp vinegar before all meals for the past few days,
and it does seem like my insulin needs are decreasing a bit, and I have lost
a pound. It's too early to come to any conclusions, but it has got my
interest piqued.

One of the posts in another thread talked about vinegar having Acetic Acid
in it, so I searched on +Acetic +Acid +diabetes and came upon the following
article. Helping the muscles to take in glycogen instead of the glucose
being converted to lipids sounds like a very good thing for those of us with
insulin resistance.

KC

http://jn.nutrition.org/cgi/content/abstract/131/7/1973

Acetic Acid Feeding Enhances Glycogen Repletion in Liver and Skeletal Muscle
of Rats1
Takashi Fushimi2, Kenji Tayama, Masahiro Fukaya, Kaori Kitakoshi*, Naoya
Nakai*, Yoshinori Tsukamoto and Yuzo Sato*

Central Research Institute, Mitsukan Group Company Limited, Handa 475-8585,
Japan and * Research Center of Health, Physical Fitness and Sports, Nagoya
University, Nagoya 464-8601, Japan



2To whom correspondence should be addressed. E-mail: tfushimi@xxxxxxxxxxxxxx
..



To investigate the efficacy of the ingestion of vinegar in aiding recovery
from fatigue, we examined the effect of dietary acetic acid, the main
component of vinegar, on glycogen repletion in rats. Rats were allowed
access to a commercial diet twice daily for 6 d. After 15 h of food
deprivation, they were either killed immediately or given 2 g of a diet
containing 0 (control), 0.1, 0.2 or 0.4 g acetic acid/100 g diet for 2 h.
The 0.2 g acetic acid group had significantly greater liver and
gastrocnemius muscle glycogen concentration than the control group (P <
0.05). The concentrations of citrate in this group in both the liver and
skeletal muscles were >1.3-fold greater than in the control group (P > 0.1).
In liver, the concentration of xylulose-5-phosphate in the control group was
significantly higher than in the 0.2 and 0.4 g acetic acid groups (P <
0.01). In gastrocnemius muscle, the concentration of glucose-6-phosphate in
the control group was significantly lower and the ratio of
fructose-1,6-bisphosphate/fructose-6-phosphate was significantly higher than
in the 0.2 g acetic acid group (P < 0.05). This ratio in the soleus muscle
of the acetic acid fed groups was <0.8-fold that of the control group (P >
0.1). In liver, acetic acid may activate gluconeogenesis and inactivate
glycolysis through inactivation of fructose-2,6-bisphosphate synthesis due
to suppression of xylulose-5-phosphate accumulation. In skeletal muscle,
acetic acid may inhibit glycolysis by suppression of phosphofructokinase-1
activity. We conclude that a diet containing acetic acid may enhance
glycogen repletion in liver and skeletal muscle.






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