Re: More Crazy BG's
- From: Jefferson <fwroy@xxxxxxxxxxxxxxxxxxxx>
- Date: Sun, 05 Aug 2007 12:14:31 -0400
johnniemccoy@ wrote:
I guess I should have Googled before posting. Seems like vinegar is an issue.. lots of sites. Here's just one of them: http://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=2475
John
So by chance you fell into something.
Vinegar Improves Insulin Sensitivity to a High-Carbohydrate Meal in Subjects With Insulin Resistance or Type 2 Diabetes -
http://care.diabetesjournals.org/cgi/content/full/27/1/281
First, Acetic acid is contained in vinegar.
Second, Acetic acid is produced when ethanol (as in wine, beer, etc.) is
metabolized. Alan will like this note. ;)
I came across the following in a google group search of blood+glucose+
acetic+acid, but did not verify the science involved:
"...acetic acid is the next oxidation product of ethanol, and these things usually happen in sequence (actually, ethanAL, the aldehyde is next, but no matter).
But the issue is not whether CV (cider vinegar) is a magical cure-all. I believe the poster conceded that ALL vinegars have some effect. And although it is true that acetic acid itself is essentially a VERY short chain fatty acid, with no putative dietary requirements, wierder things have happened. It is curious that a wretched molecule like acetic acid should be the mainstay in salad dressings!
I maintain interest in this because of my own very wierd cravings for vinegar (and heavy cream, by the pint!), which I do not think occur in a vacuum. If I may speculate a little on acetic acid.
Acetic acid is the unactivated precursor to acetyl-CoA, which is fed right into mitochondrial TCA cycle. Other posters have assured me that acetic acid is in fact activated, like any other fatty acid, for final entry into this TCA cycle. However, it may have an advantage of not needing the transport machinery to get into the mitochondria (as do
regular activated FAs), or, it may be transportable elsewhere. It is
unusual, at the very least.
Next, acetic acid is definitely not absorbed in the same way as free fatty acids or triglycerides, as it is NOT a lipid, yet it is
metabolized as a short chain fatty acid. But in the meantime, it is
floating around in the blood as acetic acid. What is interesting about
this is that the pK of acetic acid renders it essentially intact
(un-ionized, ie, a weak acid), which gives it a certain mobility across
cell membranes, and also means it probably contributes negligibly to pH
loading, or acidifying, of the blood. (This is no doubt going to cause
furor here!) Which means it could have some small-molecule regulatory
effects. It's also handy to have around if esters need to be made.
Nothing to write home about perhaps, but interesting nonetheless.
Regarding the acidifying of blood issue, it could be that some people
need whatever amount of pH loading it does provide, or for some reason
need it as part of the blood buffering system."
The hand is quicker than the eye. ;)
Frank
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