Re: Joe Trippi, diabetic, still drinks Diet Pepsi -- now key staff for John Edwards campaign -- John and Elizabeth Edwards, Bill Clinton, Mitt Romney, *** Cheney, George Bush, Tony Blair, also use aspartame soda: Murray 2007.05.04

Blindly and ignorantly shooting the messenger undermines the
effectiveness of your own valuable, sizable support group for
supporting civil, evidence-based debate of toxicity issues, which
gravely impact the genesis, prevention, and treatment of diabetes.

The newsgroup bionet.toxicology, moderated by Assc. Prof. Charles A.
Miller III of Tulane University, has recently accepted two of my long
scientific review posts, including:

formaldehyde as a potent unexamined cofactor in cancer research --
sources include methanol, dark wines and liquors, aspartame, wood and
tobacco smoke: IARC Monographs on the Evaluation of Carcinogenic Risks
to Humans implicate formaldehyde in #88 and alcohol drinks in #96:
some related abstracts: Murray 2007.04.30
http://groups.yahoo.com/group/aspartameNM/message/1417

Has he been deceived by a liar?

Please specify evidence that I am a seller of stevia, if you want to
succeed in your mission of warning fellow diabetics against what you
believe to be a toxic sweetener.

In mutual service, Rich Murray


www.som.tulane.edu/cancer/TCCnames/facm.html

Charles A. Miller III, Ph.D. [ photo ]
Associate Professor of Environmental Health Sciences
TCC Program Member rellim@xxxxxxxxxx
(504) 988-6942, fax (504) 988-1762
1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Homepage on the EHS website:
http://www.ehs.tulane.edu/Faculty-Profiles/Miller-Chuck.html

Biographical Narrative:

Dr. Miller received a Bachelor of Science degree in biology from the
University of Alabama in Birmingham.
He worked as a research associate in the Pharmacology and Biochemistry
Departments and the Cancer Center at the University of Alabama in
Birmingham, studying anti-malarial drug toxicity with Roy Mundy,
chemical carcinogenesis with Awni Sarrif, colon cancer biology with
Michael Brattain, and the immunology of natural killer cells with Toru
Abo and Charles Balch.
He joined Max Costa's laboratory and studied carcinogenic mechanisms
of nickel and chromium compounds and earned a Doctor of Philosophy
degree in Environmental Oncology from the Sackler School of Basic
Medical Sciences of New York University.
During this time he was the recipient of a fellowship from Shell Oil
Company.
His post-doctoral research was conducted in David Kowalski's
laboratory at Roswell Park Cancer Institute.
There he described several new DNA replication origins in yeast.
He is presently an Associate Professor in the Environmental Health
Sciences Department at Tulane University School of Public Health and
Tropical Medicine.
His research interests include understanding the regulation of the
aryl hydrocarbon (dioxin) receptor by Hsp90 and co-chaperone proteins
and understanding the effects of various ligands on this signaling
pathway.

Recent Publications:

* Vujcic M, Miller III CA, Kowalski D. Activation of silent
replication origins at ARS elements near the HML locus in budding
yeast. Mol Cell Biol, 19:6098-109, 1999.
* Miller III CA, Umek RM, Kowalski D. The inefficient ribosomal
DNA origin of Saccharomyces cerevisiae contains an ARS consensus
sequence and a DNA unwinding element that are functionally
compromised. Nucleic Acids Res, 27:3921-30, 1999.
* Miller III CA. A human aryl hydrocarbon receptor signaling
pathway constructed in yeast displays additive responses to ligand
mixtures. Toxicol Appl Pharmacol, 160: 297-303,1999.
* Adachi J, Mori Y, Matsui S, Takigami H, Fujino J, Kitagawa H,
Miller III CA, Kato T, Saeki K, Matsuda T. Indirubin and indigo are
potent aryl hydrocarbon receptor ligands present in human urine. J
Biol Chem in press, 2001
* Miller III CA. Tetratricopeptide repeat-containing proteins
facilitate signaling by the human aryl hydrocarbon receptor-Arnt
complex expressed in yeast, Submitted.
* Cox M, Miller III CA. Genetic evidence that the p23 co-chaperone
regulates human dioxin receptor signaling in a yeast model system.
Submitted.


He approved this:

formaldehyde as a potent unexamined cofactor in cancer research --
sources include methanol, dark wines and liquors, aspartame, wood and
tobacco smoke: IARC Monographs on the Evaluation of Carcinogenic Risks
to Humans implicate formaldehyde in #88 and alcohol drinks in #96:
some related abstracts: Murray 2007.04.30
http://groups.yahoo.com/group/aspartameNM/message/1417

[ See also:

http://groups.yahoo.com/group/aspartameNM/message/1286
methanol products (formaldehyde and formic acid) are main
cause of alcohol hangover symptoms [same as from similar
amounts of methanol, the 11% part of aspartame]:
YS Woo et al, 2005 Dec: Murray 2006.01.20


http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition:
Bouchard M et al, full plain text, 2001: substantial
sources are degradation of fruit pectins, liquors,
aspartame, smoke: Murray 2005.04.02 ]


" Absorbed formaldehyde can be oxidized to formate and carbon dioxide
or can be incorporated into biologic macromolecules. "

[ References include: Soffritti M, Belpoggi F, Lambertini L, Lauriola
M, Padovani M, Maltoni C. 2002. Results of long-term experimental
studies on the carcinogenicity of formaldehyde and acetaldehyde in
rats. Ann NY Acad Sci 982:87-105.

Soffritti M, Maltoni C, Maffei F, Biagi R. 1989. Formaldehyde: an
experimental multipotential carcinogen. Toxicol Ind Health 5:699-730.
"

Morando Soffritti is a member of the Working Group. ]


http://www.ehponline.org/members/2005/7542/7542.html free full text

After a thorough discussion of the epidemiologic, experimental, and
other relevant data, the working group concluded that formaldehyde is
carcinogenic to humans, based on sufficient evidence in humans and in
experimental animals.

In the epidemiologic studies, there was sufficient evidence that
formaldehyde causes nasopharyngeal cancer, "strong but not sufficient"
evidence of leukemia, and limited evidence of sinonasal cancer.

The working group also concluded that 2-butoxyethanol and 1-tert-
butoxy-2-propanol are not classifiable as to their carcinogenicity to
humans, each having limited evidence in experimental animals and
inadequate evidence in humans.

These three evaluations and the supporting data will be published as
Volume 88 of the IARC Monographs. PMID: 16140628


Environ Health Perspect. 2005 Sep; 113(9): 1205-8.
Meeting report: summary of IARC monographs on formaldehyde, 2-
butoxyethanol, and 1-tert-butoxy-2-propanol.

* Cogliano VJ, Vincent James Cogliano cogliano@xxxxxxx,
* Grosse Y, Yann Grosse grosse@xxxxxxx,
* Baan RA, Robert A. Baan baan@xxxxxxx,
* Straif K, Kurt Straif, straif@xxxxxxx,
* Secretan MB, Marie Béatrice Secretan secretan@xxxxxxx,
* El Ghissassi F, Fatiha El Ghissassi elghissassi@xxxxxxx,
* Working Group for Volume 88.


http://monographs.iarc.fr/ENG/Staff/index.php
photo of Carcinogen Identification and Evaluation Group - Staff

Secretariat: Tel. +33 (0)4 72 73 85 07 Fax +33 (0)4 72 73 83 19

Head of Programme, Vincent James Cogliano

Secretary, Helene Lorenzen-Augros

Scientists:
Robert Baan (genetic toxicology)
Fatiha El Ghissassi (biochemistry/genetic toxicology)
Yann Grosse (carcinogenesis/bioassays)
Béatrice Secretan (molecular toxicology)
Kurt Straif (epidemiology)

Technical Assistants:
Sandrine Egraz
Martine Lézère
Jane Mitchell

IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France
Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75
© IARC 2004 - All Rights Reserved
http://monographs.iarc.fr cie@xxxxxxx,

Monographs Recently Published

IARC Monographs Vol 88
Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol

December 2006
478 pages
ISBN 92 832 1288 6
US$ 40

This volume re-evaluates the available evidence on the carcinogenic
potential of formaldehyde, a substance that is found in the workplace
and in the environment.
Formaldehyde is widely used in resins that bind wood products, pulp
and paper; in glasswool and rockwool insulation; in plastics and
coatings, textile finishing, chemical manufacture; and as a
disinfectant and preservative. Also evaluated are two glycol ethers,
2-
butoxyethanol and 1-tert-butoxypropan-2-ol, which are widely used as
solvents in paints and paint thinners, coatings, glass and surface
cleaners, inks, adhesives, personal-care products, and as chemical
intermediates.
As for formaldehyde, there is sufficient evidence in epidemiological
studies for nasopharyngeal cancer, strong but not sufficient evidence
for leukaemia, and limited evidence for sinonasal cancer.
The extensive scientific database on the mechanisms by which
formaldehyde can induce nasal-tract cancer in humans is considered.
These data provide strong support for the empirical observation of
nasopharyngeal cancer in humans.
In contrast, the lack of information on possible mechanisms by which
formaldehyde might increase the risk for leukaemia in humans tempered
the interpretation of the epidemiological data on that cancer.
Although this volume focuses on a qualitative assessment of the
carcinogenic potential of formaldehyde, subsequent predictions of the
risks for nasopharyngeal cancer should consider pertinent information
on mechanisms of carcinogenesis, including genotoxicity and dose-
dependent cytoxicity.
A theme common to the three evaluations is the consideration of
mechanistic information to develop and evaluate hypotheses on the
sequence of steps that lead to the induction of tumours in
experimental animals.
The hypothesized mechanisms described provide an interesting set of
cases that range from a vast literature on respiratory tract tumours
in rats induced by the inhalation of formaldehyde to some more
tentative hypotheses on the various tumours observed in animals
following exposure to both glycol ethers.
Recurring issues were the criteria that characterize a rare tumour or
how to introduce additional information to resolve difficult
questions; for example, how to consider the results of historical
controls.

International Agency for Research on Cancer, Lyon, France.

An international, interdisciplinary working group of expert
scientists met in June 2004 to develop IARC Monographs on the
Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC
Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-
propanol.

Each IARC Monograph includes a critical review of the pertinent
scientific literature and an evaluation of an agent's potential to
cause cancer in humans.

Key words: 1-tert-butoxy-2-propanol, 2-butoxyethanol, carcinogen,
formaldehyde, glycol ethers, hazard identification, IARC Monographs,
leukemia, nasopharyngeal cancer, sinonasal cancer. Environ Health
Perspect 113: 1205-1208 (2005) . doi:10.1289/ehp.7542 available via
http://dx.doi.org/ [Online 12 May 2005]

Address correspondence to V.J. Cogliano, Carcinogen Identification
and Evaluation, International Agency for Research on Cancer, 150 cours
Albert Thomas, 69372 Lyon cedex 08, France.
Telephone: 33-4-72-73-84-76. Fax: 33-4-72-73-83-19. E-mail:
cogliano@xxxxxxx,

The Working Group for Volume 88 of the IARC Monographs includes:
Ulrich Andrae (Germany) , andrae@xxxxxx, Dr. Ulrich Andrae, GSF-
Institut für Toxikologie,. Postfach 1129, D-85758 Neuherberg, Germany
Fax: 149-089-3187-3449
Sherwood Burge (UK) ,
Rajendra S Chhabra (USA) , http://dir.niehs.nih.gov/dirtob/chhabra.htm
chhabrar@xxxxxxxxxxxxx, General Toxicology Group, TOB, ETP, DIR
John Cocker (UK) , Health and Safety Laboratory, Buxton, UK
john.cocker@xxxxxxxxxx,
David N Coggon (UK) , MRC Environmental Epidemiology Unit at the
University of Southampton, UK dnc@xxxxxxxxxxxxxxx,
Rory Conolly (USA) , Rconolly@xxxxxxxx, Senior Research Biologist,
National Center for Computational Toxicology, Office of Research and
Development, U.S. Environmental Protection Agency
Paul Demers (Canada) , pdemers@xxxxxxxxxxxx, Occupational Hygiene
Institute, University of British Columbia
David A Eastmond (USA) , david.eastmond@xxxxxxx, Enviromental
Toxicology Graduate Program, University of California Riverside, CA
92521 (951) 827-4497 (Voice) (951) 827-3087 (Fax)
Elaine Faustman (USA) , faustman@xxxxxxxxxxxxxxxx, Professor, Env. and
Occ. Health Sciences, Adjunct Professor, Evans School 206-685-2269
Victor J Feron (the Netherlands) , TNO Nutrition and Food Research
(retired), The Netherlands TNO-CIVO TOXICOLOGY AND NUTRITION INSTITUTE
Utrechtseweg 48 3704 HE Zeist The Netherlands (31)-3404 44 144
Michel Gérin (Canada, Chair) , gerinm@xxxxxxxxxxxxxxxx, Departement
de medecine du travail et d'hygiene du milieu, Universite de Montreal,
Quebec, Canada.
Marcel Goldberg (France) , marcel.goldberg@xxxxxxxxxxxxxxxxxxxx,
France -- National Institute of Health and Medical Research INSERM
Unite 88, HNSM 14 Rue de Val d'Osne F-94410 St. Maurice France [33]
1-451-83859 [33] 1-451-83889
Departement Sante Travail, Institut de Veille Sanitaire, 12, rue du
Val d'Osne, 94410 Saint Maurice, France
Bernard D Goldstein (USA) , bdgold@xxxxxxxx, Director of the
Environmental and Occupational Health Sciences Institute and Professor
and Chair of the Department of Environmental and Community Medicine at
UMDNJ - Robert Wood Johnson Medical School. Dean's Office, University
of Pittsburgh Graduate School of Public Health, A624 Crabtree Hall,
130 DeSoto St., Pittsburgh, PA 15261, USA.
Roland C Grafström (Sweden) , roland.grafstrom@xxxxxxxxx, Roland C
Grafström, Institute of Environmental Medicine, Karolinska Institutet,
Box 210, S−17177 Stockholm, Sweden
Telefax: +46-8−329402
Johnni Hansen (Denmark) , johnni@xxxxxxxxx, PhD, Senior researcher,
Danish Cancer Registry , Institute of Cancer Epidemiology, Danish
Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.
Michael Hauptmann (USA) , The National Cancer Institute
Kathy Hughes (Canada) , Head, Existing Substances Section 1, Health
Canada,
Ted Junghans (USA) , tjunghans@xxxxxxxxxxxx, Technical Resources
International, Inc., 6500 Rock Spring Drive, Suite 650, Bethesda, MD
20817, USA.
Dan Krewski (Canada) , MHA, MSc, PhD dkrewski@xxxxxxxxxx, Professor
Director, R. Samuel McLaughlin Centre for Population Health Risk
Assessment, Institute of Population Healt, 1 Stewart Street, Room 320,
Phone: (613) 562-5381 Fax: (613) 562-5380
Steve Olin (USA) , solin@xxxxxxxx, ILSI International Life Sciences
Institute
Martine Reynier (France) , martine.reynier@xxxxxxx, Mme Martine
REYNIER, Institut National de Recherche et de Sécurité (INRS), 30, rue
Olivier Noyer, 75680 Paris Cedex 14 (France) Tel : +33 (0)1 40 44 30
81 Fax : +33 (0)1 40 44 30 54
Judith Shaham (Israel) , yshaham@xxxxxxxxxxxx, Occupational Cancer
Department, National Institute of Occupational and Environmental
Health, Raanana, Israel. MD, Occupational Cancer Unit, Occupational
Health & Rehabilitation Institute, P.O. Box 3, Raanana 43100, ISRAEL

Morando Soffritti (Italy) , crcfr@xxxxxxxxxxxx, European Foundation
of Oncology and Environmental Sciences "B. Ramazzini", Cesare Maltoni
Cancer Research Center, Bologna, Italy

Leslie Stayner (USA) , lstayner@xxxxxxx, Division of Epidemiology and
Biostatistics, University of Illinois at Chicago School of Public
Health (M/C 923), 1603 West Taylor Street, Room 971, Chicago, IL
60612. E-mail:
Patricia Stewart (USA) , National Food Safety and Toxicology
Center, 165 Food Safety and Toxicology Building, Michigan State
University, East Lansing, MI 48824; fax (517) 432-2310
Douglas Wolf (USA) , wolf.doug@xxxxxxx, DVM, PhD, USEPA,
(Toxicology)

We gratefully acknowledge the important contributions of the
administrative staff of the IARC Monographs: S. Egraz, M. Lézère, J.
Mitchell, and E. Perez.

The IARC Monographs are supported, in part, by grants from the
U.S. National Cancer Institute, the European Commission, the U.S.
National Institute of Environmental Health Sciences, and the U.S.
Environmental Protection Agency......







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