Re: MUFA diet for T2D

"Ozgirl" <are_we_there_yet@xxxxxxxxxx> wrote in message
news:133kip8kjgfhbb1@xxxxxxxxxxxxxxxxxxxxx

"Gys de Jongh" <G.deJongh@xxxxxxxxxxxxx> wrote in message
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"Nicky" <ukc802466929@xxxxxxxxxxxxx> wrote in message

Yeah. Have you spotted anyone expanding on it?

Fill me in :)

I think she means is there more research somewhere with more information?


Thanks Ozgirl :)

For me these two are the most spectacular ones because both the tube fed
patients and the mice cannot "escape" the diet rules

Conclusions :
1) high MUFA formula results in a more effective glycaemic control than the
standard diet, while being comparable in safety.

2) only MUFA-rich LFD with ALA also improved both insulin sensitivity and
glycemic responses.

hth
Gys



Eur J Clin Nutr. 2005 Nov;59(11):1221-32.
Glycaemic control in type II diabetic tube-fed patients with a new enteral
formula low in carbohydrates and high in monounsaturated fatty acids: a
randomised controlled trial.

OBJECTIVES: To investigate the effects of long-term treatment with a new
enteral formula low in carbohydrates and high in monounsaturated fatty acids
(MUFAs), in comparison with a standard formula, on glycaemic control in
tube-fed type II diabetic patients. DESIGN: Randomised, double-blind,
controlled, multi-centre trial.Setting:Early rehabilitation centres, primary
care and nursing facilities. SUBJECTS:A total of 78 patients with
insulin-treated type II diabetes with HbA(1C) > or =7.0% and/or fasting
blood glucose >6.66 mmol/l, who required enteral tube feeding due to
neurological dysphagia. INTERVENTIONS: Patients received 113 kJ (27 kcal)/kg
of body weight of either test feed or an isoenergetic, isonitrogenous
enteral formula (control) for 12 weeks. Glycaemic control (total daily
insulin dosage (IU), fasting blood glucose, and HbA(1C)) and
gastrointestinal tolerance were monitored daily. RESULTS: After 12 weeks,
median values for changes from baseline were as follows (test group vs
control group, 'data as available' analysis): total daily IUs -6.0 vs 0.0
(P=0.0024), fasting blood glucose (mmol/l) -1.59 vs -0.08 (P=0.0068);
HbA(1C) (%) -0.8 vs 0.0 (P=0.0016). Both formulas were tolerated comparably.
CONCLUSIONS:This study indicates that in tube-fed insulin-treated type II
diabetic patients, the new low-carbohydrate, high MUFA formula results in a
more effective glycaemic control than the standard diet, while being
comparable in safety.

PMID: 16077745


Metabolism. 2006 Oct;55(10):1365-74.
Differential effects of n-3 polyunsaturated fatty acids on metabolic control
and vascular reactivity in the type 2 diabetic ob/ob mouse.

Diets rich in monounsaturated fatty acids (MUFA) are recommended for
individuals with type 2 diabetes mellitus (T2DM). The American Heart
Association recommends increasing intakes of n-3 polyunsaturated fatty acids
(PUFA) to reduce the risk of vascular disease in high-risk individuals;
however, the long-term effects of these bioactive fatty acids on glucose
metabolism in insulin resistance are controversial. The present studies were
conducted to evaluate the effects of diets rich in both MUFA and alpha
linolenic acid (C18:3n-3, ALA), eicosapentaenoic acid (C20:5n-3, EPA), or
docosahexaenoic acid (C22:6n-3, DHA), on glycemic control and other
parameters related to vascular health in a mouse model of T2DM and insulin
resistance. Male ob/ob mice (n = 15 per treatment) were fed 1 of 4
lipid-modified formula diets (LFDs) for 4 weeks: (1) MUFA control, (2) ALA
blend, (3) EPA blend, and (4) DHA blend. A portion of a MUFA-rich lipid
blend in the control LFD was replaced with 11% to 14% energy as n-3 PUFA.
After 4 weeks, plasma glucose response to a standard meal (1.5 g
carbohydrate/kg body weight) and insulin challenge (2 U/kg body weight, IP)
was assessed, and samples were collected for analysis of glucose, insulin,
and lipids. Vascular reactivity of isolated aortic rings was assessed in an
identical follow-up study. The results showed that insulin-resistant mice
fed an LFD with EPA and/or DHA blends had significantly (P < .05) lower
triglycerides and free fatty acids, but insulin sensitivity and fasting
plasma glucose were not improved. However, mice fed with the ALA blend had
significantly improved insulin sensitivity when compared to those fed with
other LFD (P < .05). Animals fed an LFD with n-3 PUFA from marine or plant
sources showed significantly improved vascular responses as compared with
the MUFA-rich LFD (E(max), P < .05) and ob/ob reference mice consuming chow
(E(max) and pEC(50), P < .05). In summary, long-term consumption of LFD with
n-3 PUFAs improved blood lipids and vascular function in an animal model of
insulin resistance and T2DM; however, only MUFA-rich LFD with ALA also
improved both insulin sensitivity and glycemic responses. Further studies of
MUFA-rich LFD with ALA with individuals who have T2DM are warranted.

PMID: 16979408


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